Circadian clocks are self-sustaining timekeepers found in almost all organisms on earth. The filamentous fungus Neurospora crassa is a preeminent model for eukaryotic circadian clocks. Investigations of the Neurospora circadian clock system have led to elucidation of circadian clock regulatory mechanisms that are common to all eukaryotes. In this work, we will focus on the Neurospora circadian ...

Trimethylated lysine 27 on histone H3 (H3K27me3) is present in Drosophila, Arabidopsis, worms, and mammals, but is absent from yeasts that have been examined. We identified and analyzed H3K27me3 in the filamentous fungus Neurospora crassa and in other Neurospora species. H3K27me3 covers 6.8% of the N. crassa genome, encompassing 223 domains, including 774 genes, all of which are transcriptional...

Neurospora is among the most studied of all eukaryotes. It is a convenient organism for the study of genetic polymorphism through analysis of isozymes (Yu, Garrett & Sussman, 1971 ; Reddy & Threlkeld, 1971,1972), and the possibility of population studies with Neurospora has been demonstrated by Perkins (1970) who collected isolates from over 60 localities in the tropics. However, Perkins' colle...

In the red bread mold Neurospora crassa as in other pyrenomycetes the sexual spores, the ascospores, germinate only after the application of heat (Shear and Dodge, 1927; Goddard, 1935, 1938, 1939). When treated at a temperature of from 50 to 60 C for periods varying from 10 to 60 minutes the spores will germinate up to 100 per cent. Germination may occur without this treatment, the percentage d...

In the fungus Neurospora crassa, hexagonal crystalline inclusions have been observed with both the light and electron microscopes. These crystals have been enriched by differential centrifugation and found to be identical with ergosterol by the criteria of ultraviolet spectral analysis and cytochemical analysis. Observations have been made on the distribution and fine structure of the crystalli...

Electrophoretic and immunological analysis of fruiting body (perithecial) extracts demonstrates the occurrence of a major phase-specific perithecial protein in all Neurospora species and in the closely related Gelasinospora cerealis and Sordariafimicola. The perithecial proteins from these different species fall into a number of groups with different electrophoretic mobilities. They appear to b...

Bobb, Dolores (Palo Alto Medical Research Foundation, Palo Alto, Calif.), Dorothy Liebes, and David A. Salzberg. Effect of azo dyes on growth and metabolism of Neurospora crassa. I. Relative resistance of Neurospora strains to azo dye inhibition. J. Bacteriol. 84:242-249. 1962.-Under conditions where growth factors were not limiting, 3'-methyl-4-monoaminoazobenzene, a rat hepatocarcinogen, inhi...