Neuropathological features and causes of death are presented in 27 deceased patients belonging to a prospective series of 71 hospitalised patients with primary degenerative dementia. The clinical criteria for primary degenerative dementia used in the present study were accurate enough to exclude patients with multi-infarct dementia. At necropsy, 82% of the cases had neuropathological changes of...

Abstract Background Glioblastoma (GBM) is an aggressive type of brain cancer that prevalent and fatal in the elderly. Age not only most common risk factor for but also neurodegenerative diseases, previous studies have indicated excess co-occurrence both diseases. Here, we aim to map Alzheimer (AD)-related pathology GBM-adjacent cortex. Material Methods To this end, screened a cohort 99 individu...

Myotonic dystrophy (DM1) is known to be an adult-onset muscular dystrophy caused by the expansion of CTG repeats within the 3' untranslated region of the dystrophin myotonin protein kinase (DMPK) gene. The clinical features of DM1 include CNS symptoms, such as cognitive impairment and personality changes, the pathogenesis of which remains to be elucidated. We hypothesized that the distribution ...

Gaucher disease (GD), the most common lysosomal storage disorder, is caused by a deficiency in the lysosomal enzyme glucocerebrosidase (GlcCerase), which results in intracellular accumulation of glucosylceramide (GlcCer). The rare neuronopathic forms of GD are characterized by profound neurological impairment and neuronal cell death, but little is known about the neuropathological changes that ...

CONTEXT The hallmark pathological changes in Alzheimer disease (AD) are abundant plaque and tangle formation, especially in the temporal lobes and hippocampus. Although there is increasing evidence that major depression may interact with neuropathological processes in AD, there have been no studies of neuropathological changes in AD as a function of history of major depression. OBJECTIVE To t...

will be missed. Each author must do his best, and the editor, advised by his referees, must judge whether that best is good enough. If the editor decides to publish his readers can judge and comment, either privately or in the correspondence column of the journal, if prior claims have been overlooked. They frequently do. Alzheimer's disease: recent advances and future prospects Recent years hav...

The number of studies that have investigated the neuropathology of mild cognitive impairment (MCI) is small, but growing. In this paper we have restricted our focus to the consideration of the presence and extent of postmortem findings relevant to the neuropathology of Alzheimer's disease. We have drawn from studies that have investigated the postmortem neurobiology of the brains of persons wit...