Spinal muscular atrophy (SMA) is a genetic disorder which affect nervous system and is characterized with progressive distal motor neuron weakness. The survival motor neuron (SMN) protein level reduces in patients with SMA. Two different genes code survival motor neuron protein in human genome. Skeletal and intercostal muscles denervation lead to weakness, hypotony, hyporeflexia, respiratory fa...

delayed neuronal death after seizure attack may be mediated by the induction of apoptosis-pathway. caspase-3, a mammalian cysteine protease, promotes apoptosis after some neurological disorders. neuron regeneration peptides (nrps) are small synthetic peptides that stimulate neural proliferation, migration, and differentiation with no apparent toxicity and high target specificity in cns. in the ...

in this study organotypic adult spinal cord slices were used to investigate whether caspases could participate in the apoptosis of motor neurons. the thoracic region of spinal cord was sliced using a tissue chopper and cultured in a medium for 6h. morphological and biochemical features of apoptosis were assessed by fluorescent staining and terminal deoxynucleotidyl nick end labeling (tunel) met...

introduction: (s)- 3,5-dihydroxyphenylglycine (dhpg) is an agonist for group i metabotropic glutamate receptors. dhpg-induced synaptic depression of excitatory synapses on hippocampal pyramidal neurons is well known model for synaptic plasticity studies. the aim of the present study was to examine the effects of dhpg superfusion on excitatory synapses on pyramidal and fast-spiking gabaergic cel...

spinal muscular atrophy (sma) is a genetic disorder which affect nervous system and is characterized with progressive distal motor neuron weakness. the survival motor neuron (smn) protein level reduces in patients with sma. two different genes code survival motor neuron protein in human genome. skeletal and intercostal muscles denervation lead to weakness, hypotony, hyporeflexia, respiratory fa...

Cell-gene therapy is a dynamic constituent of novel medical biotechnology. Neurodegenerative disordersin which damage to or demise of specific brain cell types plays central role, are clear examples of diseasecandidate for cell replacement therapy. Dopaminergic (DAergic) neurons biosynthesize dopamine, a vitalneurotransmitter in the central nervous system. Due to the involveme...

background and objective: deprenyl is a drug for the treatment of parkinson’s disease, where the dopaminergic neurons are the target of this drug. several reports also documented that deprenyl has an effect on the sensory and motor neurons. there are some reports about the mode of action of deprenyl on motoneurons as a neuroprotective agent, while others believe that deprenyl acts as a neurores...

the n-methyl-d-aspartic acid (nmda) receptor is one of the specific types of ionotropic receptors which lied to glutaminergic system. it has been widely accepted that nmda receptor neurons promote anxiety, in humans as well as in animal models. however, in the previous study seems inhibiting of this receptors decreased the protective role in neural cell. demonstration of nmda receptor activity ...