results brdu ihc showed a significant decrease in neurogenesis following tld in both sexes showing more severity in male rats than in female rats. results of nissl staining and mwm also confirmed the brdu findings. regarding sexual dimorphism, our data showed no significant sex differences in the dg area of the hippocampus. conclusions sex-dependent reduction in neurogenesis following tld could...

objective(s): in the past few decades, variety of foetal, embryonic and adult stem and progenitor cells have been tried with conflicting outcome for cell therapy of central nervous system injury and diseases. cellular characteristics and functional plasticity of globose basal stem cells (gbcs) residing in the olfactory epithelium of rat olfactory mucosa have not been studied in the past by the ...

Neurogenesis is the combined processes of division, migration and differentiation neural stem cells (NSCs). The two different locations: subventricular zone (SVZ) lateral ventricle subgranular (SGZ) in hippocampus dentate gyrus (DG), provide a niche environment for neurogenesis. Neurotrophic factors have roles on migration, proliferation NSC progenitor cells. Studies shown that NSCs regulator...

adult neurogenesis is a process of producing nerve cells from their progenitor that occurs in some areas in the brain such as the hypothalamus. low activity in this area plays a role in neural degeneration and diseases such as multiple sclerosis, epilepsy and depression. ms is a neurodegenerative disease with a permanent disability that the main reason for it is axonal degeneration and neuronal...

background: mellitus diabetes (dm) is the most important metabolic diseases. the incidence of dm is prone to increase. vasculopathy, retinopathy, central and peripheral neuropathy are the most important reported side effects of dm. cognitive dysfunction following dm reported in both sexes. hippocampus is a major part of brain involving in cognitive function, its cells are able to neurogenesis, ...

conclusions these results suggest a negative correlation between mdma administration and adult hippocampal neurogenesis. results our results showed that mdma administration caused a decrease in neun expression in the experimental group compared with the control group. objectives due to the effect of neurogenesis on memory and learning, in this study, we investigated the effects of mdma on neun ...

Introduction: The administration of 3,4-methylenedioxymethamphetamine (MDMA) or ecstasy causes memory impairment, whereas neurogenesis improves memory and learning. Hence, this study evaluated the effects of MDMA on neurogenesis in the hippocampus of male rats. Methods: Adult male Wistar rats received intraperitoneal (IP) injections of MDMA (10 mg/kg). We assessed nestin, sex-determining regio...

This review explores the effects of fructose on hippocampus: hippocampal function and structure, neurogenesis, cognitive function. First, this result confirms that excess intake affects microstructure pathways connecting hippocampus to other brain areas. Fructose has potential affect neurogenesis in hippocampus, a diet high can impair learning memory, leading impairment. However, further resear...

spinal cord injury (sci)-induced systemic inflammatory response affects multiple organs outside the spi­nal cord. treatment options for such complications are lacking. valproic acid (vpa) is a histone deacetylase inhibitor, acting directly at the level of gene transcription by inhibiting histone deacetylation and making transcription sites more accessible. acetylation of histones is critical to...