نتایج جستجو برای: neuraminidase

تعداد نتایج: 5883  

Journal: :iranian journal of pharmaceutical research 0
poonam inamdar department of pharmaceutical chemistry- pg wing, aissms college of pharmacy, pune-01, maharashtra, india. shashikant bhandari department of pharmaceutical chemistry- pg wing, aissms college of pharmacy, pune-01, maharashtra, india. bhagyashri sonawane department of pharmaceutical chemistry- pg wing, aissms college of pharmacy, pune-01, maharashtra, india. asha hole department of pharmaceutical chemistry- pg wing, aissms college of pharmacy, pune-01, maharashtra, india. chintamani jadhav department of pharmaceutical chemistry- pg wing, aissms college of pharmacy, pune-01, maharashtra, india.

the urgent need of neuraminidase inhibitors (ni) has provided an impetus for understanding the structure requisite at molecular level. our search for selective inhibitors of neuraminidase has led to the identification of pharmacophoric requirements at various positions around acyl thiourea pharmacophore. the main objective of present study is to develop selective ni, with least toxicity and dru...

Journal: :The EMBO journal 1998
A van der Spoel E Bonten A d'Azzo

Human lysosomal N-acetyl-alpha-neuraminidase is deficient in two lysosomal storage disorders, sialidosis, caused by structural mutations in the neuraminidase gene, and galactosialidosis, in which a primary defect of protective protein/cathepsin A (PPCA) leads to a combined deficiency of neuraminidase and beta-D-galactosidase. These three glycoproteins can be isolated in a high molecular weight ...

Journal: :Journal of bacteriology 1966
R T Kelly D Greiff S Farmer

Kelly, R. T. (Marquette University School of Medicine, Milwaukee, Wis.), D. Greiff, and S. Farmer. Neuraminidase activity in Diplococcus pneumoniae. J. Bacteriol. 91:601-603. 1966.-A method for the quantitation of neuraminidase in the presence of N-acetylneuraminic acid aldolase is described. The neuraminidase content of Diplococcus pneumoniae was found to be dependent on the media employed for...

2012
Gillian M. Air

Influenza neuraminidase is the target of two licensed antivirals that have been very successful, with several more in development. However, neuraminidase has been largely ignored as a vaccine target despite evidence that inclusion of neuraminidase in the subunit vaccine gives increased protection. This article describes current knowledge on the structure, enzyme activity, and antigenic signific...

Journal: :Journal of Biological Chemistry 2000

Journal: :The Journal of antimicrobial chemotherapy 2015
Rubaiyea Farrukee Sook-Kwan Leang Jeff Butler Raphael T C Lee Sebastian Maurer-Stroh Danielle Tilmanis Sheena Sullivan Jennifer Mosse Ian G Barr Aeron C Hurt

OBJECTIVES The burden of disease due to influenza B is often underestimated. Clinical studies have shown that oseltamivir, a widely used neuraminidase inhibitor (NAI) antiviral drug, may have reduced effectiveness against influenza B viruses. Therefore, it is important to study the effect of neuraminidase mutations in influenza B viruses that may further reduce NAI susceptibility, and to determ...

Journal: :Journal of virology 1973
A P Kendal M P Kiley

Neuraminidases (EC 3.2.1.18) of 1957, 1960, and 1969 influenza virus strains were isolated after proteolytic digestion of viral hemagglutinin. Each neuraminidase was recovered with a final yield of about 15% and had similar specific activities. Immunization of rabbits with the neuraminidases elicited monospecific neuraminidase antibodies, with no antibodies to viral hemagglutinin. Further evide...

Journal: :FEBS letters 1990
G T van der Horst U Rose R Brossmer F W Verheijen

ASA-NeuAc2en, a photoreactive arylazide derivative of sialic acid, is shown to be a powerful competitive inhibitor of lysosomal neuraminidase from bovine testis (Ki approximately 21 microM). Photoaffinity labeling and partial purification of preparations containing this lysosomal neuraminidase activity result in specifically and non-specifically labeled polypeptides. Only labeling in a 55 kDa p...

Journal: :Infection and immunity 1984
S Kabir N Ahmad S Ali

Vibrio cholerae O1 strains belonging to both biotypes (classical and El Tor) and both serotypes (Ogawa and Inaba) produced neuraminidase which was released rather than cell bound. Classical strains made more neuraminidase than did El Tor strains. About one-third of V. cholerae non-O1 strains and one-fourth of Aeromonas hydrophila strains were neuraminidase positive. Strains of enterotoxigenic E...

Journal: :Antiviral research 2005
O Ferraris N Kessler B Lina

Influenza virus neuraminidase inhibitors (NAIs) were introduced in clinical practice in various parts of the world since 1999 but were only scarcely distributed in France. Prior to the generalization of zanamivir and oseltamivir utilization in our country, we decided to test a large panel of influenza strains to establish the baseline sensitivity of these viruses to anti-neuraminidase drugs, ba...

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