Although cisplatin is one of the most widely used anticancer drugs, nephrotoxicity remains a major doselimiting side effect. To reduce the incidence of cisplatin-induced nephrotoxicity, we analyzed possible risk factors in 349 patients who received cisplatin (15-120 mg/m2) for the first cycle of chemotherapy between April 2011 and March 2014. Nephrotoxicity was defined as serum creatinine eleva...

BACKGROUND Most chemotherapeutic drugs are known to cause nephrotoxicity. Therefore, new strategies have been considered to prevent chemotherapy-induced nephrotoxicity. It is of note that Nigella sativa (NS), or its isolated compound Thymoquinone (TQ), has a potential role in combating chemotherapy-induced nephrotoxicity. AIM To analyze and report the outcome of experimental animal studies on...

the clinical uses of gentamicin have so far been restricted due to nephrotoxicity and ototoxicity. the exact mechanism of nephrotoxicity is still unknown; however, it appears that free radicals may be involved. methionine has previously been shown to alleviate oxidative stress involved in ototoxicity due to its antioxidant properties. therefore, the effect of methionine supplementation on the g...

Nephrotoxicity associated with vancomycin is a commonly feared and mainly preventable adverse effect. Non-severe cases of nephrotoxicity resolve upon discontinuation the medication. We present case 45-year-old man who developed renal dysfunction following antibiotic therapy as result lack dose adaptation to measured serum nadirs.

Gentamicin nephrotoxicity limit its usage against gram negative bacteria. Most researches showed that antioxidant agents improved gentamicin nephrotoxicity. According to these investigations oxidative stress play a central role in the mechanism of gentamicin induced nephrotoxicity. Recently Rafieian-Kopaei and colleagues showed that erythropoietin significantly ameliorated serum creatinine, blo...

OBJECTIVE This study evaluates the cost-effectiveness of vancomycin serum concentration monitoring in patients with hematologic malignancies. METHODS The study was designed as a prospective randomized study. Seventy immunocompromised febrile patients with hematologic malignancies were randomly assigned to either a vancomycin therapeutic drug monitoring group (TDM group; n = 37) or to a contro...

The use of the calcineurin inhibitors cyclosporine and tacrolimus led to major advances in the field of transplantation, with excellent short-term outcome. However, the chronic nephrotoxicity of these drugs is the Achilles' heel of current immunosuppressive regimens. In this review, the authors summarize the clinical features and histologic appearance of both acute and chronic calcineurin inhib...

INTRODUCTION The increasing trend of extensively drugresistant gram negative bacteria responsible for nosocomial infections has prompted resurgence colistin usage. Colistin-induced nephrotoxicity is a concern with disparity in the reported rates between previous studies. This study aims to evaluate colistin-induced nephrotoxicity among Malaysian population. METHODS The medical records of ICU ...

OBJECTIVES Polymyxin B is an active agent against many MDR Gram-negative bacteria, but nephrotoxicity is a major hindrance to its widespread use. To guide its optimal use, we determined the risk factors for nephrotoxicity onset associated with polymyxin B. METHODS In a multicentre, retrospective, cohort study, we evaluated adult patients with normal renal function who received ≥72 h of polymy...

In an effort to maximize outcomes, recent expert guidelines recommend more-intensive vancomycin dosing schedules to maintain vancomycin troughs between 15 and 20 mg/liter. The widespread use of these more-intensive regimens has been associated with an increase in vancomycin-induced nephrotoxicity reports. The purpose of this systematic literature review is to determine the nephrotoxicity potent...