Whereas it is generally perceived to be harmful, enhanced coagulation activation can also convey salutary effects. The high prevalence of the prothrombotic factor V Leiden (FVL) mutation in whites has been attributed to a positive selection pressure (eg, resulting from reduced blood loss or improved survival in sepsis). The consequences of enhanced coagulation activation, as observed in FVL car...

This study was designed to evaluate the protective effect of nebivolol, beta-1 blocker, on the nephrotoxicity induced by gentamicin in male albino rats. The protective effect of silymarin, as natural antioxidant, and acetylcystein, as nephroprotective agent were compared. The results revealed that three weeks of nebivolol administration prior to gentamicin, protected the rats from the oxidative...

Whereas it is generally perceived to be harmful, enhanced coagulation activation can also convey salutary effects. The high prevalence of the prothrombotic factor V Leiden (FVL) mutation in whites has been attributed to a positive selection pressure (eg, resulting from reduced blood loss or improved survival in sepsis). The consequences of enhanced coagulation activation, as observed in FVL car...

Natural products and dietary components have earlier been proven as potential chemoprotective agents, and continuous efforts are in progress to search for such new products. Gentamicin, an aminoglycoside antibiotic, is widely used for treating the infections caused by many gram negative bacteria. However, besides other unwanted effects, the drug causes tubular cell necrosis in the proximal conv...

Renal disorders have become very common nowadays, which may also lead to kidney failure. The disorder may be caused by the commonly used chemicals such as acetaminophen, CCl4, streptromycin, H2O2 etc. The objective of this work is to determine the nephroprotective potential of ethanolic extract against H2O2 induced toxicity in VERO cell line. Ethanolic extract is known for its antioxidant, anti...

This study investigated the nephroprotective effect of curcumin against acetaminophen (APAP)induced nephrotoxicity in rats. APAP-induced nephrotoxicity was evident by a significant increase (P<0.01) of urea and creatinine in serum. Furthermore, a significant increase (P<0.01) of lipid peroxidation as malondialdehyde (MDA), nitric oxide (NO), protein carbonyl (PC) contents, interleukin-1β(IL-1β)...

Protective effect of Camellia Sinensis L. leaf extract on lead acetate Induced nephrotoxicity in albino wistar rats were investigated by analyzing various biochemical parameters. Lead acetate induced kidney damage was well manifested by significant increase in renal parameters like urea, uric acid creatinine and serum electrolytes sodium, potassium,chloride, calcium, phosphorous and TBARS and d...

BACKGROUND Homonoia riparia is a plant, which is widely used in the indigenous system of medicine for the treatment of urolithiasis, renal disorders and inflammatory conditions. This is the first report on the antioxidant and nephroprotective activities of whole plant of H. riparia. OBJECTIVE The present study aims at investigating the in vitro antioxidant and nephroprotective activity of the...

This research aims at studying the nephroprotective properties of BNO 2103 in a model chromate-induced renal failure rats and proving possibility using clinical practice for complex treatment chronic kidney disease (CKD). Materials methods. Fifty divided into five groups were studied. The drugs 2103, Prednisolone Lespephril administered within 20 days. excretory function functional state kidney...

Chronic kidney disease (CKD) is a major public health problem worldwide. Rhubarb has been shown to have nephroprotective and anti-fibrotic activities in patients with CKD. However, bioactive fractions and biochemical mechanism of anti-fibrotic properties of rhubarb remain unclear. Here we applied ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry together with u...