Gonorrhea may become untreatable, and new treatment options are essential. We investigated the in vitro activity of the first fluoroketolide, solithromycin. Clinical Neisseria gonorrhoeae isolates and reference strains (n = 246), including the two extensively drug-resistant strains H041 and F89 and additional isolates with clinical cephalosporin resistance and multidrug resistance, were examine...

INTRODUCTION Gonorrhea is one of the most common sexually transmitted infections (STls) in developing countries, and the emergence of resistance to antimicrobial agents in Neisseria gonorrhoeae is a major obstacle in the control of gonorrhoea. Periodical determination of the prevalence and monitoring of antimicrobial susceptibility of N. gonorrhoeae is essential for the early detection of emerg...

The perplexing clinical course of a 23-year-old black male with isolated gonococcal pulmonary valvular endocarditis is presented. M-mode echocardiography provided the first clue to the presence of pulmonary valvular vegetations and the proper diagnosis. Since Neisseria gonorrhea appears to have a particular affinity for the pulmonary valve, the presence of isolated pulmonary valvular endocardit...

The perplexing clinical course of a 23-year-old black male with isolated gonococcal pulmonary valvular endocarditis is presented. M-mode echocardiography provided the first clue to the presence of pulmonary valvular vegetations and the proper diagnosis. Since Neisseria gonorrhea appears to have a particular affinity for the pulmonary valve, the presence of isolated pulmonary valvular endocardit...

The perplexing clinical course of a 23-year-old black male with isolated gonococcal pulmonary valvular endocarditis is presented. M-mode echocardiography provided the first clue to the presence of pulmonary valvular vegetations and the proper diagnosis. Since Neisseria gonorrhea appears to have a particular affinity for the pulmonary valve, the presence of isolated pulmonary valvular endocardit...

Sir, Chlamydia trachomatis and Neisseria gonorrhea are the leading reportable causes for sexually transmitted diseases (STDs) in the United States.[1,2] In UK, gonorrheal disease is considered the second most common sexually transmitted infection of bacterial origin.[3] In France, the average number of Neisseria gonorrhea isolated per laboratory per year decreased from 10.6 in 1986 to 0.6 in 19...

Urethral or cervical swab of 255 patients attending Skin and Social Hygiene Centre and found positive for gram negative intracellular diplococci on direct microscopy were inoculated on Modified New York City (MNYC) medium and chocolate (heated blood) agar for isolation of neisseria gonorrhea. Growth of N. gonorrhea was obtained in 134 (52.5%) cases. These strains were tested for penicillin susc...

Abstract Neisseria gonorrhoeae is a human-specific pathogen, causing the sexually transmitted disease gonorrhea. Gonococci are adapted at evading immune response, but although an uncomplicated infection can be easily treated, increase in antibiotic resistance cause of concern. Here we present our latest contributions to N. research, elucidating various aspects and role known novel pathogenicity...

Two antigen preparations, the soluble antigen and a fraction 1 thereof, isolated in the course of a systematic study of the various antigens of the virulent gonococcus, have been investigated for their ability to serve as antigens for the detection of antibody in patients infected with the gonococcus. The soluble antigen was reactive with 88.2% of the sera from infected females, and fraction 1 ...

Neisseria gonorrheoae is the causative agent of gonorrhea, a sexually transmitted infection responsible for major burden disease with high global prevalence. Protective immunity to often not observed in humans, possible due variability key antigens, induction blocking antibodies, or large number infections being relatively superficial and inducing strong immune response. N. gonorrhoeae strictly...