This study was to determine the correlation between endothelial function and neuro-endocrine-immune (NEI) network through observing the changes of NEI network under the different endothelial dysfunction models. Three endothelial dysfunction models were established in male Wistar rats after exposure to homocysteine (Hcy), high fat diet (HFD) and Hcy+HFD. The results showed that there was endothe...

Escherichia coli possesses two DNA glycosylase/apurinic lyase activities with overlapping substrate specificities, endonuclease III and endonuclease VIII, that recognize and remove oxidized pyrimidines from DNA. Endonuclease III is encoded by the nth gene. Endonuclease VIII has now been purified to apparent homogeneity, and the gene, nei, has been cloned by using reverse genetics. The gene nei ...

OBJECTIVE To estimate the relative contributions of central vision loss and general health to vision-targeted quality of life as measured by the National Eye Institute Visual Function Questionnaire (NEI-VFQ). METHODS Data on quality of life (NEI-VFQ and the 36-Item Short-Form Health Survey [SF-36]) and visual acuity were collected as part of the Submacular Surgery Trials Pilot Study. Informat...

PURPOSE To evaluate the vision-related quality of life (VR-QOL) in patients undergoing vitrectomy for epiretinal membrane (ERM) removal and to investigate the relationship between VR-QOL and the severity of pre/postoperative metamorphopsia. DESIGN Prospective, interventional, consecutive, comparative case series. METHODS The 25-item National Eye Institute Visual Function Questionnaire (NEI ...

BACKGROUND The NEI VFQ-25 has undergone psychometric evaluation in patients with varying ocular conditions and the general population. However, important limitations which may affect the interpretation of clinical trial results have been previously identified, such as concerns with reliability and validity. The purpose of this study was to evaluate the National Eye Institute Visual Functioning ...

PURPOSE To test the assumption that the National Eye Institute Visual Function Questionnaire (NEI VFQ) measures visual functioning, assess the validity of its subscales, and, if flawed, revise the questionnaire and derive a shortened version with sound psychometric properties. SETTING Flinders Medical Centre, Adelaide, Australia. METHODS Patients from the cataract surgery waiting list self-...

As a nonspecific physical stimulation, the effect of acupuncture on diseases is produced by motivating the inherent regulatory system in the body, having the characteristics of whole regulation, dual directional regulation, etc. Modern scientific researches show that body's inherent regulatory system is neuro-endocrine-immune (NEI) network. Hence, we speculate that the regulatory effect of acup...

This symposium was held on June 1-2, 2009 at NIH. The meeting was organized by NEI and jointly supported by NEI and NIBIB as a part of the NEI 40th Anniversary Symposia Series. The meeting brought together many of the world’s leading experts in ocular imaging technology to discuss the current state of the art in optical coherence tomography (OCT), adaptive optics (AO), fluorescence imaging, and...

PURPOSE To study mouse trabecular meshwork (TM) and to develop a murine TM cell line. METHODS Mouse TM in situ was studied by light and electron microscopy (EM). In addition, TM was isolated from the H-2K(b)-tsA58 transgenic mouse strain in which promoter sequences of the major histocompatibility complex H-2Kb class 1 gene are fused to sequences of the SV40 mutant temperature-sensitive (ts) s...

OBJECTIVE To develop and test the psychometric properties of a 25-item version of the National Eye Institute Visual Function Questionnaire (NEI VFQ-25). DESIGN Prospective observational cohort study of persons with 1 of 5 chronic eye diseases or low vision who were scheduled for nonurgent visits in ophthalmology practices and a reference sample of persons without eye disease. SETTING Eleven...