PURPOSE To evaluate the feasibility of administering NSC 655649, a water-soluble rebeccamycin analogue that inhibits both topoisomerases I and II, in combination with cisplatin (CDDP) in adults with solid malignancies. Major toxicologic and pharmacologic differences between the two sequences of drug administration were also assessed. EXPERIMENTAL DESIGN NSC 655649 was administered as a 60-min...

This article presents a control scheme in the stationary reference frame for static synchronous compensators (STATCOMs) that provide three features: 1) regulation of positive-sequence voltage to nominal value; 2) full cancellation negative-sequence voltage; and 3) peak limitation injected currents. These features can help improve performance these devices under perturbed grid conditions, includ...

This paper presents a vector current controller (in the synchronous reference, or dq, frame) with negative-sequence injection capability for three-phase grid-connected converters. is desired operation of converter during unbalanced conditions and also certain type islanding detection. The proposed first determines double-frequency references then uses sixth-order two-input two-output proportion...

The allocation of nonstructural carbon (NSC) to growth, metabolism and storage remains poorly understood, but is critical for the prediction of stress tolerance and mortality. We used the radiocarbon ((14) C) 'bomb spike' as a tracer of substrate and age of carbon in stemwood NSC, CO2 emitted by stems, tree ring cellulose and stump sprouts regenerated following harvesting in mature red maple tr...

We know surprisingly little about whole-tree nonstructural carbon (NSC; primarily sugars and starch) budgets. Even less well understood is the mixing between recent photosynthetic assimilates (new NSC) and previously stored reserves. And, NSC turnover times are poorly constrained. We characterized the distribution of NSC in the stemwood, branches, and roots of two temperate trees, and we used t...

Neural stem cells (NSCs) can self-renew and give rise to neurons, astrocytes and oligodendrocytes. NSCs are found in the central nervous system (CNS) of mammalian organisms, and represent a promising resource for both fundamental research and CNS repair. Animal models of CNS damage have highlighted the potential benefit of NSC-based approaches. Here we review the progress in the field of NSC bi...

During the past decades Neural Stem Cells have been considered as an alternative source of cells to replace lost neurons and NSC transplantation has been indicated as a promising treatment for neurodegenerative disorders. Nevertheless, the current understanding of NSC biology suggests that, far from being mere spare parts for cell replacement therapies, NSCs could play a key role in the pharmac...