[Purpose] This study aimed to determine the effectiveness and mechanisms of extracorporeal shock wave therapy in the treatment of femoral head osteonecrosis. [Subjects and Methods] Histomorphometric analysis of necrotic femoral head in rabbits treated with shock waves was performed. Bilateral osteonecrosis of femoral heads was induced with methylprednisolone and lipopolysaccharide in eight rabb...

We investigate a multiphase Cahn–Hilliard model for tumor growth with general source terms. The approach allows us to consider multiple cell types and chemical species (oxygen and/or nutrients) that are consumed by the tumor. Compared classical two-phase models, can be used describe stratified exhibiting several layers of tissue (e.g., proliferating, quiescent necrotic tissue) more precisely. O...

Antibiotic prophylaxis may be useful in acute necrotising pancreatis, a disease associated with a considerable incidence of infectious complications. The aim of this study was to assess pefloxacin penetration into necrotic pancreatic tissue during human necrotic pancreatitis. Ten patients (mean age 53.2 +/- 17.4 years) with severe acute pancreatitis (mean Ranson score 4.3) were studied. Pefloxa...

Introduction: In recent studies using MR imaging, poor results of worsening pain in patients with osteonecrosis of the femoral head were reported in 23% to 62% [1–3]. The necrotic volume was reported to be one of the most significant factors for worsening of hip pain [4]. Bone marrow edema at the femoral head and neck was reported to be observed in patients with osteonecrosis, having a strong a...

PURPOSE To investigate whether high-resolution images of necrotic regions in tumors can be derived from gadopentetate dimeglumine (Gd-DTPA)-based dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) series. MATERIALS AND METHODS E-13 human melanoma xenografts were used as preclinical models of human cancer. DCE-MRI was performed at a voxel size of 0.23 x 0.47 x 2.0 mm3 with the use ...

The goal of this study was to determine dominant factors affecting treatment response in pancreatic cancer photodynamic therapy (PDT), based on clinically available information in the VERTPAC-01 trial. This trial investigated the safety and efficacy of verteporfin PDT in 15 patients with locally advanced pancreatic adenocarcinoma. CT scans before and after contrast enhancement from the 15 patie...

Abstract High-intensity focused ultrasound (HIFU) is a promising therapy for thermal ablation and hyperthermia, characterized by its non-invasiveness high penetration depth. Effective HIFU thermo-therapy requires the ability to accurately predict temperature elevation corresponding dose distribution in target tissues. We report parametric numerical study of response soft tissue ultrasound. comp...

BACKGROUND AND OBJECTIVES The relationship between the positive remodeling (PR) of a coronary artery and plaque composition has been studied only in a relatively small number of study population or non-culprit lesion. We evaluated the association between coronary plaque composition and coronary artery remodeling in a relatively large number of culprit lesions. SUBJECTS AND METHODS The study p...