Non-coding RNAs (ncRNA) account for a large portion of the transcribed genomic output. This diverse family of untranslated RNA molecules play a crucial role in cellular function. The use of 'deep sequencing' technology (also known as 'next generation sequencing') to infer transcript expression levels in general, and ncRNA specifically, is becoming increasingly common in molecular and clinical l...

RNA is transcribed from DNA, and therefore, there should be no RNA transcript from the deleted DNA region. Our study attempted to analyse whether any RNA cache that maps the deleted regions is present in human cells. Using data from the 1000 genome project, we selected 41 CEPH (CEU) and 38 Yoruba (YRI) samples that included the data for the entire genome sequence and ncRNA and mRNA sequences. A...

Accumulating evidence suggests that diverse non-coding RNAs (ncRNAs) are involved in the progression of a wide variety of diseases. In recent years, abundant ncRNA-disease associations have been found and predicted according to experiments and prediction algorithms. Diverse ncRNA-disease associations are scattered over many resources and mammals, whereas a global view of diverse ncRNA-disease a...

Noncoding RNAs (ncRNAs), particularly microRNAs (miRNAs) and long ncRNAs (lncRNAs), are important players in diseases and emerge as novel drug targets. Thus, unraveling the relationships between ncRNAs and other biomedical entities in cells are critical for better understanding ncRNA roles that may eventually help develop their use in medicine. To support ncRNA research and facilitate retrieval...

Non-coding RNAs (ncRNAs) are versatile regulators in cellular networks. While most trans-acting ncRNAs possess well-defined mechanisms that can regulate transcription or translation, they generally lack the ability to directly sense cellular signals. In this work, we describe a set of design principles for fusing ncRNAs to RNA aptamers to engineer allosteric RNA fusion molecules that modulate t...

Large-scale studies of mammalian genome transcription reveal that a large proportion of the genome is transcribed. It remains an open question whether the identified transcripts are functional. Here, we searched for computational evidence to support the functionality of 34,030 noncoding RNA (ncRNA) transcripts reported by the Fantom3 project. We show that compared to control sets, the Fantom nc...

RESUMEN: El cáncer de mama (CM) en varones es una enfermedad rara, ya que se trata menos del 1% los cánceres detectados. Por ello importante encontrar formas prevenir este tipo enfermedades y saber por qué producen si existe algún factor genético predispone a padecer cáncer. En sentido, sabe algunos RNA no codificantes (ncRNA) están involucrados el CM mujeres, pero hay nada descrito referente s...