As one of the most intensively studied transcription factors, it is unsurprising that p53 is involved in many biological processes, including cell cycle arrest, DNA repair, senescence and apoptosis.1 its activities are mainly regulated by posttranslational modifications and interactions with other cellular components. Over the past few years, p53 has also been linked to redox homeostasis, the b...

As one of the most intensively studied transcription factors, it is unsurprising that p53 is involved in many biological processes, including cell cycle arrest, DNA repair, senescence and apoptosis.1 its activities are mainly regulated by posttranslational modifications and interactions with other cellular components. Over the past few years, p53 has also been linked to redox homeostasis, the b...

As one of the most intensively studied transcription factors, it is unsurprising that p53 is involved in many biological processes, including cell cycle arrest, DNA repair, senescence and apoptosis.1 its activities are mainly regulated by posttranslational modifications and interactions with other cellular components. Over the past few years, p53 has also been linked to redox homeostasis, the b...

STUDY BACKGROUND Chronic granulomatous Disease (CGD) is a rare immunodeficiency caused by a defect in the leukocyte NADPH oxidase. This enzyme generates superoxide, which is needed for the killing of bacteria and fungi by phagocytic leukocytes. Most CGD patients have mutations in CYBB, the X-linked gene that encodes gp91phox, the catalytic subunit of the leukocyte NADPH oxidase. We report here ...

As one of the most intensively studied transcription factors, it is unsurprising that p53 is involved in many biological processes, including cell cycle arrest, DNA repair, senescence and apoptosis.1 its activities are mainly regulated by posttranslational modifications and interactions with other cellular components. Over the past few years, p53 has also been linked to redox homeostasis, the b...

As one of the most intensively studied transcription factors, it is unsurprising that p53 is involved in many biological processes, including cell cycle arrest, DNA repair, senescence and apoptosis.1 its activities are mainly regulated by posttranslational modifications and interactions with other cellular components. Over the past few years, p53 has also been linked to redox homeostasis, the b...

Typhoid fever and salmonellosis, which are caused by Salmonella typhi and typhimurium, respectively, are responsible for significant morbidity and mortality in both developed and developing countries. We model typhoid fever using mice infected with Salmonella typhimurium, which results in a systemic disease, whereby the outcome of infection is variable in different inbred strains of mice. This ...

Rheumatoid arthritis (RA) is a chronic inflammatory disease with a heritability of 60%. Genetic contributions to RA are made by multiple genes, but only a few gene associations have yet been confirmed. By studying animal models, reduced capacity of the NADPH-oxidase (NOX) complex, caused by a single nucleotide polymorphism (SNP) in one of its components (the NCF1 gene), has been found to increa...