BACKGROUND AND PURPOSE The Prevention of VTE after Acute Ischemic Stroke with LMWH (PREVAIL) study demonstrated that enoxaparin was superior to unfractionated heparin (UFH) in preventing venous thromboembolism in patients with ischemic stroke and was associated with a small but statistically significant increase in extracranial hemorrhage rates. In this PREVAIL subanalysis, we evaluate the long...

BACKGROUND AND PURPOSE Age and National Institutes of Health Stroke Scale early after stroke onset have been identified as important determinants of final stroke outcome. We analyzed the Virtual International Stroke Trials Archive (VISTA) database to define the influence of infarct or hemorrhagic volume on clinical outcome after stroke. METHODS All patients were extracted from VISTA where inf...

BACKGROUND AND PURPOSE A number of factors have been associated with postthrombolysis intracerebral hemorrhage, but these have varied across studies. METHODS We examined patients with acute ischemic stroke treated with intravenous tissue plasminogen activator within 3 hours of symptom onset who were enrolled in the placebo arms of 2 trials (Stroke-Acute Ischemic NXY Treatment [SAINT] I and II...

BACKGROUND AND PURPOSE On top of functional outcome, accurate prediction of cognitive outcome for stroke patients is an unmet need with major implications for clinical management. We investigated whether stroke location may contribute independent prognostic value to multifactorial predictive models of functional and cognitive outcomes. METHODS Four hundred twenty-eight consecutive patients wi...

background: the aim of this study was to evaluate whether higher serum levels of insulin-like growth factor-i (igf-i) in the acute phase of ischemic stroke are associated with less severe strokes and better functional outcome in a period of 12-month follow-up. methods: from october 2014 to august 2015, patients with the diagnosis of acute ischemic stroke admitted to the stroke unit of firoozgar...

BACKGROUND AND PURPOSE We investigate whether admission serum calcium levels are associated with hematoma volume, stroke severity, and outcomes in patients with acute intracerebral hemorrhage. METHODS A total of 273 patients admitted within 24 hours after intracerebral hemorrhage onset was divided into quartiles based on admission serum calcium levels (Q1 [≤9.0], Q2 [9.1-9.3], Q3 [9.4-9.7], Q...

Background: Among different mechanisms, oxidative stress has a possible role in neural injury in cerebrovascular events. Objectives: Assessment the oxidants-antioxidants imbalance in ischemic and hemorrhagic strokes. Materials and Methods: Serum level of malondialdehyde, the main marker of lipid peroxidation, and total antioxidant capacity were measured in a group of 48 stroke patients consis...

BACKGROUND Randomized trials of thrombolytic stroke treatment have either excluded patients with posterior circulation ischemia or used inclusion criteria making enrollment of these patients less likely. Consequently, there is less published information on thrombolytic therapy for posterior circulation stroke. OBJECTIVE To determine effective thrombolytic treatment times for posterior circula...