The effects of exogenous histamine on nasal mucosal blood flow and the systemic activity of intranasally administered desmopressin, a vasopressin analogue, were studied in normal volunteers. Ten subjects received either saline or histamine (1, 20, 100, and 500 pg) by intranasal spray. Maximal nasal mucosal blood flow response, determined by laser doppler velocimetry, demonstrated a signifcant (...

The effects of exogenous histamine on nasal mucosal blood flow and the systemic activity of intranasally administered desmopressin, a vasopressin analogue, were studied in normal volunteers. Ten subjects received either saline or histamine (1, 20, 100, and 500 micrograms) by intranasal spray. Maximal nasal mucosal blood flow response, determined by laser doppler velocimetry, demonstrated a sign...

We report on a case of limited form of granulomatosis with polyangiitis (GPA) with pituitary involvement which presented with central diabetes insipidus. This rare form of GPA has not been reported in Korea. The patient presented with fever, headache, productive cough, nasal symptoms, and polyuria. Laboratory data and imaging studies demonstrated inflammatory lesions in nasal sinus and lungs. P...

arginine vasopressin as a supplementary vasopressor in septic shock restores vascular tone and mean arterial pressure, meanwhile decreases dose and exposure time to catecholamines. the objective of this study was to evaluate the effect of vasopressin on lactate and lactate clearance as markers of tissue perfusion during septic shock. in this prospective, randomized, controlled trial, 30 patient...

Vasopressins are evolutionarily conserved peptide hormones. Mammalian vasopressin functions systemically as an antidiuretic and regulator of blood cardiac flow essential for adapting to terrestrial environments. Moreover, acts centrally a neurohormone involved in social parental behavior stress response. Vasopressin synthesis several cell types, storage intracellular vesicles, release response ...

the vasopressin v2 receptor belongs to the large family of the g-protein coupled receptors and is responsible for the antidiuretic effect of the neurohypophyseal hormone arginine vasopressin (avp). based on bioinformatic studies it seems that ala300 and asp297 of the v2 vasopressin receptor (v2r) are involved in receptor binding. ala300glu mutation resulted in lower energy while asp297tyr mutat...

INTRODUCTION The development of intradialytic hypotension during hemodialysis (HD) in which fluid removal is the primary goal, contributes to the excessive morbidity that is associated with the dialysis procedure. MATERIALS AND METHODS In a double blinded clinical trial, we compared the possible effect of intranasal DDAVP with intranasal distilled water as a placebo in prevention of intradial...

choanal polyps are a form of nasal polyps that grow toward the choana with a single stalk. septochoanal polyp is a rare entity that originates from the mucosa of the nasal septum with choanal extension. the most common site of its origin is mainly the superior aspect of the posterior portion of the nasal septum. however, metaplastic ossification is a rare event in nasal polyp and to the best of...