PURPOSE Chronic rhinosinusitis with nasal polyps (CRSwNP), a mainly Th2 cytokine-mediated disease, often involves mucus secretion. Recent evidence suggests that transmembrane protein 16A (TMEM16A), a calcium-activated Cl- channel (CaCC), can regulate mucus secretion from airway epithelium by transepithelial electrolyte transport and hydration. However, the role of TMEM16A in mucin production/se...

The long-standing observations that respiratory secretions contain virus-neutralizing substances (1-3) have recently been extended by the demonstration that antibody activity associated with the yA-globulin in nasal secretion may protect against respiratory virus infection (4). Since protection was most clearly seen in individuals with relatively high titers of nasal antibody, and since yA-glob...

Leukotrienes have been implicated as important mediator in a bronchial asthma. The purpose of this study is to evaluate the degree of participation of leukotrienes on onset of symptoms of nasal allergy. We measured leukotriene C4 and D4 (LTC4 and LTD4) in nasal secretion by radioimmunoassay combined with high performance liquid chromatography. This method is superior to the one previously repor...

To examine whether cysteinyl leukotrienes (cysLTs: LTC4, LTD4 and LTE4) induce symptoms of allergic rhinitis via their receptors, we studied the following: i) the specific binding of radiolabeled cysLTs to guinea pig nasal mucosa membrane and ii) effects of nasal LTD4 challenge in normal guinea pigs. The binding study indicated that there was a single population of binding sites for LTC4, LTD4 ...

BACKGROUND There is promising but conflicting evidence to recommend the addition of probiotics to foods for prevention and treatment of allergy. Based on previous studies with fermented milk containing Lactobacillus paracasei NCC2461, we aimed to compare the effect of a powder form of the latter probiotic with the effect of a blend of Lactobacillus acidophilus ATCC SD5221 and Bifidobacterium la...

allergic patients during the pollen season. Nasal tissues appear to play a critical role in this rise because levels of IgE to these allergens may be inhibited by intranasal steroids administered during the season.1,2 Sodium chloride nasal irrigation is an old home remedy used for rhinitis relief with a presumably rather simple action: nasal cleansing and secretion removal. Here we have assesse...

OBJECTIVES/HYPOTHESIS The role of fungi in chronic rhinosinusitis (CRS) is still controversial. The present study was conducted to detect and identify fungal species from the nasal polyp tissues of eosinophilic and noneosinophilic CRS, and to determine the role of fungal antigens in cytokine production. STUDY DESIGN Prospective study. METHODS Thirty-five specimens of nasal polyps were colle...

Hypertonic saline (HS) is used in sputum induction studies. However, little is known about the physiological effects of HS on human airways in vivo. The present study takes advantage of the fact that the airway effects of topical challenges may be accurately examined in the readily accessible nasal airway. The present study specifically examines whether exposure to HS affects histamine challeng...