In a subset of aspirin-tolerant asthmatics, administration of aspirin improves respiratory symptoms. We present a patient with chronic rhinosinusitis with nasal polyps who exhibited relief of nasal obstruction and nasal discharge and improvement in the sense of smell following oral administration of 150 mg of aspirin daily. Improvement in the patency of the nasal passages was documented by nas...

BACKGROUND Oxygen therapy is usually combined with a humidification device, to prevent mucosal dryness. Depending on the cannula design, oxygen can be administered pre- or intra-nasally (administration of oxygen in front of the nasal ostia vs cannula system inside the nasal vestibulum). The impact of cannula design on intra-nasal humidity, however, has not been investigated to date. OBJECTIVE...

Recent studies have considered oxytocin (Oxt) as a possible medicine to treat obesity and hyperphagia. To find the effective and safe route for Oxt treatment, we compared the effects of its nasal and intraperitoneal (IP) administration on food intake, locomotor activity, and glucose tolerance in mice. Nasal Oxt administration decreased food intake without altering locomotor activity and increas...

Recently, nasal route has received a great deal of attention as a method for systemic administration of drugs, especially those that have to be administered by injection. The nasal route is advantageous because of the rapid absorption of drug molecules across the nasal mucosa and the relative ease of administration (1). Nasal powder formulations may improve chemical and microbiologic stability ...

Objective: In pediatric nuclear medicine efforts to reduce the distress of the child is essential. Sedation is indicated when other means are not sufficient. The choice of sedative and the route of administration are important issues. Midazolam administered intranasally has proven to be safe and efficient. In this study we have compared midazolam given as nasal drops with midazolam given as nas...

BACKGROUND Detection of Pneumocystis jiroveci colonization in lungs or oral samples due to high sensitivity of PCR methods results in undue treatment of patients without any symptoms of Pneumocystis pneumonia. The aim of the present study is to demonstrate Pneumocystis carinii in rats, immune suppressed by oral and subcutaneous administration of dexamethasone. MATERIAL/METHODS Blood, oral, na...

 The aim of me present work was to investigate rhe potential utility of nanoparticles made of chitosan (CS) and also CS chemically modified with polyethylene glycol (CS-PEG) as new vehicles for improving na^al vaccine delivery. For mis purpose, diphtheria toxoid (DT) was chosen as a model antigen. DT was entrapped within nanoparticles made of CS of different molecular weight, and also made of C...

Morphine administered nasally to humans as a simple solution is only absorbed to a limited degree, with a bioavailability of the order of 10% compared with intravenous administration. This article describes the development of novel nasal morphine formulations based on chitosan, which, in the sheep model, provide a highly increased absorption with a 5- to 6-fold increase in bioavailability over ...

Both the increased nasal vascular permeability and eosinophil accumulation were commonly observed in nasal mucosa with allergic rhinitis. Topical administration of platelet-activating factor (PAF) produced dose-dependent increases in nasal vascular permeability concomitant with the increase in both the histamine and leukotriene C4 (LOC4) concentrations of nasal lavage fluid, in non-sensitized g...