A nuclear wave-packet description of the photodissociation of LiF is described, with emphasis on the dynamics associated with the formation of long-lived resonances. The predissociation is described using ab initio potential-energy curves and transition dipole matrix elements. The split operator method is used to propagate time-dependent coupled-channel wave functions in a diabatic representati...

immunosuppressants require therapeutic drug monitoring because of their narrow therapeutic index and significant inter-individual variability in blood concentrations. this variability can be because of factors like drug-nutrient interactions, drug-disease interactions, renal-insufficiency, inflammation and infection, gender, age, polymorphism and liver mass. drug monitoring is widely practiced ...

We study the midinfrared plasmonic response in Bernal-stacked bilayer graphene. Unlike its monolayer counterpart, bilayer graphene accommodates optically active phonon modes and a resonant interband transition at infrared frequencies. They strongly modify the plasmonic properties of bilayer graphene, leading to Fano-type resonances, giant plasmonic enhancement of infrared phonon absorption, a n...

Immunosuppressants require therapeutic drug monitoring because of their narrow therapeutic index and significant inter-individual variability in blood concentrations. This variability can be because of factors like drug-nutrient interactions, drug-disease interactions, renal-insufficiency, inflammation and infection, gender, age, polymorphism and liver mass. Drug monitoring is widely practiced ...

In their paper “Design strategies to minimize the radiative efficiency of global warming molecules,” Bera et al. (1) mistakenly equate the relative magnitudes of integrated absorption within the atmospheric window (800–1,400 cm) with relative radiative efficiencies of different molecules. Radiative efficiency is defined as the change in net radiation at the tropopause caused by a given change i...

One approach for delivery of narrow absorption window drugs is to formulate gastroretentive drug delivery systems. This study was undertaken to provide insight into in vivo performances of two gastroretentive systems (PXLNET and IPB matrices) in comparison to Madopar® HBS capsules. The pig model was used to assess gastric residence time and pharmacokinetic parameters using blood, cerebrospinal ...

Introduction: Radiation therapy is one of the major modalities that have long been used in cancer treatment. Radiotherapy is often accompanied by early and late toxicity and side effects and narrow therapeutic window. Similarity in radiation absorption properties of tumors and neighboring healthy tissues is often the reason for low specificity of radiation therapy. Development ...

mellitus. Its biological half life is 2.5 to 3 hours. Due to its short biological half life and narrow absorption window, it is incompletely absorbed in the small intestine. It is a strong base (pKa = 11.5), protonated depending on the physiological pH of the human body. It is also poorly absorbed in the colon. However, reduction of gastrointestinal motility enhances the drug absorption. Most o...

Hydrogels, such as those based on poly(2-hydroxyethyl methacrylate) (PHEMA), are hydrophilic three dimensional network structures that undergo extensive swelling in water. PolyHIPEs are highly porous, crosslinked polymers typically synthesized within high internal phase emulsions (HIPEs). This research describes materials with enhanced water absorption that combine hydrogel water absorption wit...

Oral controlled release and site specific drug delivery system has been of great interest in pharmaceutical field to achieve improved therapeutic advantage. Drug absorption in the gastrointestinal tract is a highly variable procedure and prolonging gastric retention of the dosage form extends the time for drug absorption. Gastro retentive drug delivery system is one of such novel approaches to ...