The roots of Nardostachys jatamansi have been used as a substitute for valerian in Iranian traditions. Moreover, six species from Valeriana genus such as V. sisymbriifolia grow in Iran which has not been studied yet. We aimed to study of antioxidant effect of Valeriana officinalis, Nardostachys jatamansi and Valeriana sisymbriifolia and comparing their content of valerenic acid and valepotriate...

Nardostachys jatamansi DC. and Selinum vaginatum (Edgew) Cl. are two endemic high altitude Indian medicinal plants that have been traditionally known as "Jatamansi" and "Bhootkeshi," respectively. These are used in various traditional herbal formulations and nutraceuticals, as well as to treat neurological disorders like epilepsy, hysteria, syncope, convulsions, and mental weakness. They resemb...

The cholinergic hypothesis of Alzheimer's disease (AD) has provided the rationale for the current pharmaco-therapy of this disease, in an attempt to reduce the cognitive decline caused by cholinergic deficits. Nevertheless, the search for potent and long-acting acetylcholinesterase (AChE) inhibitors that exert minimal side effects in AD patients is still ongoing. AChE inhibitors are currently t...

The Nardostachys jatamansi DC (NJ) root has been used as a sedative or analgesic to treat neurological symptoms and pain in traditional Korean medicine. Here, we investigate the potential effects of NJ on Alzheimer's disease (AD) and reveal the molecular mechanism through which NJ exerts its effects. The neuroprotective effect of the NJ root ethanol extract against β amyloid (Aβ) toxicity was e...

The rhizomes of Nardostachysjatamansi, the plant commonly known as Jatamansi have been described in Ayurveda for their soothing and sedative action on the central nervous system. In the present study, the anti-stress effect of hydroethanolic extract (70%) of N. jatamansi (NJE) was evaluated in reference to its antioxidant property. Wistar rats were divided into four groups: naive, stressed, and...

Medicinal plants are in rich source of antimicrobial agents. The present study was carried out to evaluate the antibacterial and antifungal effect of five important plants namely, Andrographis paniculata, Bacopa monnieri, Centella asiatica, Nardostachys jatamansi ,Saraca indica. The preliminary phytochemical analysis was tested by using different extract of these plants for the presence of vari...

The present study was undertaken to evaluate Tagara and Jatamansi for certain CNS activities to ascertain the basis for their use as a sedative and hypnotics. The drugs were evaluated for hypnotic and sedative, anti anxiety, anti depressant and anti psychotic activities using standard experimental protocol. The data generated suggests that the test drugs Tagara and Jatamansi have complex CNS ac...

Introduction: Nardostachys jatamansi DC. is an important ayurvedic plant. The root and rhizome contain active compounds with carminative, sedative, antispasmodic and tranquilizing properties. It is also used as an insect repellent. Essential oil from the drug shows antimicrobial activity against a number of microorganisms. Method: The present study comprises microscopic and macroscopic studies,...

Nardostachys jatamansi DC also known as Indian Spikenard or Indian Valerian, is a valued medicinal plant of family Valerianaceae. This rhizome bearing plant is native of the Himalayas of India and Nepal and preferably found from 2200 m to 5000 m asl in random forms. The extract of rhizome is widely used in the formulation of traditional Ayurvedic medicines as well as modern herbal preparations ...