Background: Narcotic abuse and addiction have recently emerged as significant global issues. The consumption of dependence-inducing substances has become increasingly prevalent among younger generations in numerous countries, exacerbating the problem. Until 2015, South Korea had been relatively narcotic-free; however, this is no longer true. Consequently, encountering narcotic abusers clinical ...

Narcotic analgesics cause addiction by poorly understood mechanisms, involving mu opoid receptor (MOR). Previous cell culture studies have demonstrated significant basal, spontaneous MOR signaling activity, but its relevance to narcotic addiction remained unclear. In this study, we tested basal MOR-signaling activity in brain tissue from untreated and morphine-pretreated mice, in comparison to ...

The Classification of Psychoactive Drugs Sedative Hypnotics and Antianxiety Agents Focus on Disorders: Fetal Alcohol Syndrome Antipsychotic Agents Antidepressants Focus on Disorders: Depression Narcotic Analgesics Stimulants Drugs, Experience, Context, and Genes Tolerance Sensitization Addiction and Dependence Explaining Drug Abuse Behavior on Drugs Why Doesn’t Everyone Abuse Drugs? Can Drugs C...

The viscosity and ultrasound velocity of narcotic analgesic drugs in aqueous mixtures of methanol, ethanol and 1propanol have been studied.. Various acoustical parameters have been obtained which include viscous relaxation time (Γ), free volume (Vf), internal pressure (πi) and molar cohesive energy (MCE). The dependence of these properties on solvent composition is found to originate from hydro...

Background: The problem of addiction is one of the four global crises. These patients are more vulnerable to mental disorders. This study aimed to examine the risk of suicide in drug dependent patients. Methods: In this cross-sectional study, patients who referred for addiction treatment were selected and the control group was chosen among their companions who did not have narcotic drugs depend...

BACKGROUND The negative consequences of narcotic use and diversion for nonmedical use are on the rise. A growing number of narcotic abusers obtain narcotic prescriptions from multiple providers ("doctor shopping"). This study sought to determine the effects of multiple postoperative narcotic providers on the number of narcotic prescriptions, duration of narcotics, and morphine equivalent dose p...

Research on the mode of action of narcotic analgesic drugs and the mechanism of the development of tolerance and physical dependence is one of the oldest of scientific pursuits. For many years the first step in the action of these drugs was postulated to be their binding to highly specific "receptor" sites. This specific drug-receptor interaction was thought to trigger certain chemical or physi...

The mu opioid receptor (MOR, OPRM)--the principal receptor involved in narcotic addiction--has been shown to display basal (spontaneous, constitutive) signaling activity. Interaction with other signaling proteins, such as calmodulin, regulates basal MOR activity. Providing a mechanism for long-lasting regulation, basal MOR activity potentially plays a key role in addiction, in combination with ...