Antigen-specific immunotherapy is the only curative approach for the treatment of allergic diseases such as Japanese cedar pollinosis. Immunotherapy using a T cell epitope vaccine in combination with the adjuvant R848 is of particular interest as a safe and effective approach to treat allergic diseases. Herein, we propose a simple and easy to handle vaccine administration method using the origi...

this study aimed to determine the aerosolization behavior of a nanodispersion of budesonide, prepared using microfluidic reactors. the size and morphology of budesonide nanoparticles were characterized by photon correlation spectroscopy (pcs) and transmission electron microscopy (tem). processing/formulation parameters for formation of the nanoparticles were studied to determine their effects o...

In this paper we report on ZnS nanoparticles produced by precipitation of zinc acetate and sodium sulphide and stabilized by cetyltrimethylammonium bromide (CTAB) in aqueous media and deposited on montmorillonite (MMT). For the deposition a new method based on intensive cavitation was used. The montmorillonite carrier was first disintegrated by intense turbulent mixing in an ultrasonic field in...

This study aimed to determine the aerosolization behavior of a nanodispersion of budesonide, prepared using microfluidic reactors. The size and morphology of budesonide nanoparticles were characterized by photon correlation spectroscopy (PCS) and transmission electron microscopy (TEM). Processing/formulation parameters for formation of the nanoparticles were studied to determine their effects o...

The simple nematic mesogen 5CB was doped with milled BaTiO3 nanoparticles and was investigated with x-ray scattering. Doping with BaTiO3 nanoparticles of 9 nm in diameter led to the formation of crystallites. These crystallites precipitated and formed a waxlike nanodispersion of 5CB and nanoparticles, which led to intense x-ray scattering signals characteristic of a multilayer structure. Surpri...

Nanodispersion systems allow incorporation of lipophilic bioactives, such as astaxanthin (a fat soluble carotenoid) into aqueous systems, which can improve their solubility, bioavailability, and stability, and widen their uses in water-based pharmaceutical and food products. In this study, response surface methodology was used to investigate the influences of homogenization time (0.5-20 minutes...

Postoperative inflammation after cataract surgery can prolong visual recovery time, increase the treatment burden and elevate risk of poor outcomes. Corticosteroids are potent anti-inflammatory agents that have been used successfully for decades to treat ocular inflammation. However, side effects associated with topical corticosteroids including increased intraocular pressure, formation long-te...