BACKGROUND Based on our preclinical findings, we are assessing the efficacy of intratumoral injection of dendritic cells (DC) transduced with an adenoviral vector expressing the secondary lymphoid chemokine (CCL21) gene (Ad-CCL21-DC) in a phase I trial in advanced non-small cell lung cancer (NSCLC). While this approach shows immune enhancement, the preparation of autologous DC for CCL21 genetic...

The aim of this study was to design, synthesize and optimize chlorpromazine hydrochloride (CPZ)-loaded, poly-ε-caprolactone (PCL) based nanocapsules, intended for site specific delivery to the frontal lobe, using a novel melt-dispersion technique that is non-arduous, inexpensive and devoid of any hazardous organic solvents. Experimental trials using a central composite design were performed on ...

Direct excitation of acenaphthylene molecules included in a syn fashion within the octa acid nanocapsule dimerizes quantitatively to a syn dimer, and upon triplet sensitization, yields both syn and anti dimers probably by reacting within and outside the capsule.

The design of nanocapsules for targeted delivery of therapeutics presents many, often seemingly self-contradictory, constraints. An algorithm for predicting the physicochemical characteristics of nanocapsule delivery and payload release using a novel allatom, multiscale technique is presented. This computational method preserves key atomic-scale behaviours needed to make predictions of interact...

Noni (Morinda citrifolia L.) is one of the many herbs which known as an anticancer agent. Nanoencapsulated form noni extracts could help body absorption and able to inhibit proliferation cancer cells in vitro. This study was conducted examine activity nanoencapsulated vivo anti-proliferation agent cells. extract obtained by maceration method using water a solvent. The nanocapsule made ionic gel...

The efficient photoinduced electron transfer from a stilbene derivative incarcerated within a negatively charged organic nanocapsule to positively charged acceptors (methyl viologen and a pyridinium salt) adsorbed outside and the back electron transfer were controlled by supramolecular effects.

Small RNAs, including siRNAs, gRNAs and miRNAs, modulate gene expression and serve as potential therapies for human diseases. Delivery to target cells remains the fundamental limitation for use of these RNAs in humans. To address this challenge, we have developed a nanocapsule delivery technology that encapsulates small DNA molecules encoding RNAs into a small (30 nm) polymer nanocapsule. For p...

objective: amphotericin b (amb) is an ancient antifungal drug and proper for treatment of systemic fungal infection. unfortunately, this antibiotic has shown some side effects such as nephrotoxicity. therefore, recently new amb formulated has been prepared for reduced toxicity and increased effectiveness. materials and methods: amb nanocapsules prepared from polymers such as poly d, l-lactide-...