From the aerial roots of the medicinal plant Geranium sanguineum L. a polyphenol-rich extract with strong anti-influenza activity has been isolated. To investigate its active fractions, the extract was partitioned by solvents with increasing polarity. The n-BuOH fraction contained the majority of the in vitro antiviral activity; the EtOAc fraction was the most effective one in vivo. A bioassay-...

The combined virus-inhibitory effects of a proteinaceous protease inhibitor, produced by Streptomyces sp. 225b (BF), rimantadine hydrochloride (Rim), ε-aminocaproic acid (ACA) and a polyphenol extract from Geranium sanguineum L. (PC) have been investigated on the reproduction of influenza virus A/Germany/34, strain Rostock (H7N1) in MDCK cell cultures. The simultaneous application of BF and PC,...

Percutaneous transhepatic biliary drainage (PTBD) performed in obstructive biliary disease is an effective interventional procedure for palliative treatment that alleviates jaundice or cholangitis through bile duct decompression and bile drainage. Recently, with the increase of invasive procedures such as PTBD and liver biopsy in the diagnosis and treatment of hepatobiliary and pancreatic disea...

We have found that nanobacteria, recently discovered Gram-negative atypical bacteria, can cause local calciphylaxis on the mitral valve in a setting of high-calcium X phosphorous product in the blood. We present the case of a 33-year-old man with diabetic renal failure on continuous ambulatory peritoneal dialysis who died as a result of multiple brain infarcts due to embolizations from mitral v...

UNLABELLED PREMISE OF THE STUDY Microsatellite markers were developed for Melastoma dodecandrum to investigate the genetic diversity of this species and to detect hybridization and introgression in Melastoma. • METHODS AND RESULTS Fourteen microsatellite loci were characterized by screening primers developed using two simple sequence repeat (SSR)-enriched libraries. Based on the genotyping...