A method, using capillary electrophoresis (CE) with laser-induced fluorescence (LIF) detection for analyzing chitin oligosaccharides is described. Chitin oligosaccharides were derivatized with 9-aminopyrene-1,4,6-trisulfonate (APTS) via reductive amination at 37 degrees C for 16 h (optimized conditions). The APTS-chitin oligosaccharides were analyzed using either an acidic citric acid-phosphate...

One of the major challenges in the development of targeted nanoparticles (NPs) for cancer therapy is to discover targeting ligands that allow for differential binding and uptake by the target cancer cells. Using prostate cancer (PCa) as a model disease, we developed a cell-uptake selection strategy to isolate PCa-specific internalizing 2'-O-methyl RNA aptamers (Apts) for NP incorporation. Twelv...

This project (10) evaluated audible pedestrian traffic signals (APTS) from three perspectives: 1) the patterns of use and the impact of these signals on pedestrian travel; 2) the physical characteristics of the sound emitted by the Nagoya/Traconex APTS; and, 3) the detectability of the sounds emitted by this brand of APTS. This paper, the last of three companion articles (13,14), describes the ...

Tennessee State University operates several Automatic Photoelectric Telescopes (APTs) located at Fairborn Observatory in the Patagonia Mountains of southern Arizona. The APTs are dedicated to photometric monitoring programs that would be difficult and expensive to accomplish without the advantages provided by automation. I describe the operation of two of the telescopes (0.75 and 0.80 m APTs) a...

In recent years numerous advanced malware, aka advanced persistent threats (APT) are allegedly developed by nation-states. The task of attributing an APT to a specific nation-state is extremely challenging for several reasons. Each nation-state has usually more than a single cyber unit that develops such advanced malware, rendering traditional authorship attribution algorithms useless. Furtherm...

This paper describes three studies of students in computer science, information technology, and software engineering degree courses. Aim. The aim of these studies was to evaluate the usefulness of aptitude testing as a means of recruiting undergraduate students into these courses. Method. At the start of the academic year, student volunteers were invited to complete a demographic survey and/or ...

objective(s): pharmaceutical industries are leading to improved medications that can target diseases more effectively and precisely. researchers have intended to reformulate drugs so that they may be more safely used in human body. the more targeted a drug is, the lower its chance of triggering drug resistance, a cautionary concern surrounding the use of broad-spectrum antibiotics. the aim of t...

in this report, magnetic iron oxide nanoparticles were synthesized via coprecipitation of fe2+ and fe3+ with ammonium hydroxide, and the surface of synthesized nanoparticles was organically functionalized by commercially available amine coupling agent namely, 3-aminopropyl trimethoxysilane (apts) by using well-known sol–gel method. further reaction of the synthesized fe3o4@apts core-shell magne...

Various combinations of advanced public transportation systems (APTS), including advanced transit information, demand responsive transit, and personal rapid transit, are evaluated by applying traditional travel and emissions criteria as well as consumer welfare and equity criteria. A state-of-the-practice regional travel demand model is used to simulate the travel e€ects of the APTS technologie...

Resistance toward CD95-mediated apoptosis is a hallmark of many different malignancies, as it is known from primary chronic lymphocytic leukemia (CLL) cells. Previously, we could show that miR-138 and -424 are downregulated in CLL cells. Here, we identified 2 new target genes, namely acyl protein thioesterase (APT) 1 and 2, which are under control of both miRs and thereby significantly overexpr...