OBJECTIVE Diabetes mellitus is defined as a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both or insulin resistance. Curcumin inhibits NF-κB signaling pathway. The aim of this study is evaluation of the effect of Nano-curcumin on HbA1C, fast blood glucose and lipid profile in diabetic patients. MATERIALS AND METHODS...

objective: diabetes mellitus is defined as a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both or insulin resistance. curcumin inhibits nf-κb signaling pathway. the aim of this study is evaluation of the effect of nano-curcumin on hba1c, fast blood glucose and lipid profile in diabetic patients. materials and methods:...

Background: The incidence of esophageal squamous cell carcinoma (ESCC) is increasing, causing catastrophic health burdens on communities. Curcumin has shown promise as a therapeutic agent in the treatment of colon, colorectal, pancreatic, and esophageal cancers but it has very poor bioavailability. The application of nano-carriers as drug delivery systems increases curcumin's bioavailability. C...

Conventional therapies of cancer cause serious side effects, systemic toxicity, poor quality of life of patients, accompanied with tumor resistance and recurrence which discourage their long term use. Therefore, highly precise anticancer therapies with minimal side effects are needed to be identified. Curcumin’s widespread availability, safety, low cost and anticancer activity justify its devel...

Inflammatory disorders alone or as a consequence of neurological disease affecting patients in life. Experimental models of inflammation are use to evaluate the production of inflammatory mediators at site of inflammation. Curcumin is one of the flavonoids possesses potent anti-inflammatory activity. However, because of low water solubility curcumin, its clinical application has been limited. T...

Objective(s): Aluminum phosphide (AlP) is commonly used pesticide which could cause poisoning mainly through the induction of oxidative stress. The present study aimed to evaluate the effects of nano-curcumin and curcumin on the oxidant and antioxidant system in the liver mitochondria using AIP-induced toxicity model.Materials and Methods: In this study, 36 male albino Wistar rats were ra...

 Background: Paraquat (PQ), as the most widely used herbicide in agriculture, induces poisoning in humans and animals mainly through oxidative stress. This study aimed to investigate the protective effects of nano-curcumin compared with curcumin against PQ-induced mitochondrial dysfunction. Materials and Methods: Thirty-six Wistar rats were used in this study. They were separated into 6 groups...