Herbal medicine has an old history with a broad application all over the world. Many researches have focused on the curative as well as antinociceptive effects of herbal extract. The aim of this study was to investigate the analgesic effects of Berberis vulgaris hydroethanolic extract (BVE) in male mice. 30 male mice were divided into 5 groups: control, treated by morphine, treated by ...

The role of stress in the pathogenesis of ovarian cysts is believed to be mediated by the discharge of endogenous cortisol, which inhibits LH release. Endogenous opioid peptides are involved in many responses to stress. Therefore, the aim of this study was to determine the effect of epidural administration of Naloxone (NX) on cystic regression and follicle development leading to normal oestrus ...

We have previously reported that halothane anesthesia increases extracellular concentrations of dopamine (DA) metabolites in rat striatum using in vivo microdialysis techniques. Aging induces many changes in the brain, including neurotransmission. However, the relationship between aging and changes in neurotransmitter release during inhalational anesthesia has not been fully investigated. The a...

Background: There is growing evidence indicating that neuronal calcium channels play an important role in the mechanism of Morphine dependence. Objective: To investigate the acute and long-term effects of Verapamil in Morphine dependent mice. Methods: Mice were rendered dependent on Morphine by subcutaneous injection of Morphine over a period of 5 days. The effects of acute and chronic administ...

the effects of aluminium and aluminium-citrate on some serum parameters related to carbohydrate metabolism in male wistar rats were investigated. daily intraperitoneal administrations of 1 mg/kg body weight of aluminium or aluminiumcitrate (1: 1) for 50 days led to the elevation of serum insulin by 24 or 40 percent respectively, with the concomitant decrease in serum glucose concentrations by 1...

The effects of aluminium and aluminium-citrate on some serum parameters related to carbohydrate metabolism in male Wistar rats were investigated. Daily intraperitoneal administrations of 1 mg/kg body weight of aluminium or aluminiumcitrate (1: 1) for 50 days led to the elevation of serum insulin by 24 or 40 percent respectively, with the concomitant decrease in serum glucose concentrations ...

INTRODUCTION Methadone has been used as a drug to detoxify opioid tolerance. Naloxane precipitated morphine withdrawal behaviours were attenuated by venlafaxine as an antidepressant. On the contrary, after detoxifying the opioids, spontaneous withdrawal syndrome may occur with pain sensitivity. Therefore the present study aimed to examine the effects of chronic methadone (70 mg/kg, in drinking ...

Objective: Substance use disorder (SUD) continue to be a problem for the whole world in first quarter of twenty-first century. The leading centres treatment SUD our country are Alcohol-Drug Addiction Research Treatment and Training Centres (AMATEM). In this study, we aimed examine 2017 data AMATEM outpatients province. Material Methods: study was conducted as retrospective applications between ...

This s tudy evaluates the potential ant idote action of naloxone o n e x p e r i m e n t a l l y i n d u c e d d i a z e p a m a n d f l u n i t r a z e p a m (benzodiazepines) intoxication in dogs. I t s an t ido te effects is also evaluated in a clinical sample of 8 patients suffering from f lun i t razepam intoxication. T h e clinical f indings were suggestive of ari antagonist ic act ion of...

Aims: Previous investigations have confirmed the anti-inflammatory and analgesic effects of aqueous-ethanol extract of saffron on formalin induced pain in small male mice. Since there is difference between ethanol and aqueous-ethanol extract of saffron, this study was performed in order to evaluate the effect of ethanol saffron extract on acute and chronic pain in small male mice. Materials & M...