نتایج جستجو برای: nag ادرار

تعداد نتایج: 4089  

2012
Zhi-Qiang Zhang John Higgins Choi Lee Kim Chung Chang

Nanosilver (nAg) was prepared via Tollens method using dextrin as stabilizer. The morphology, size distribution and average size of the obtained nAg were characterized using Transmission electron microscope (TEM) and Dynamic light scattering (DLS) technique. A kinetic study of toxicity of nAg on Escherichia coli (E. coli) was determined. The obtained results showed that nAg exhibits spheric sha...

2012
Mark D. Mannie J. Lori Blanchfield S. M. Touhidul Islam Derek J. Abbott

Myelin-specific induction of tolerance represents a promising means to modify the course of autoimmune inflammatory demyelinating diseases such as multiple sclerosis (MS). Our laboratory has focused on a novel preclinical strategy for the induction of tolerance to the major encephalitogenic epitopes of myelin that cause experimental autoimmune encephalomyelitis (EAE) in rats and mice. This nove...

2006
M. M. Brzóska A. Stypułkowska K. Zwierz J. Moniuszko-Jakoniuk

This paper aims to assess the relationship between the urinary activity of N-acetyl-β-D-glucosaminidase (NAG) and its isoenzyme B (NAG-B) and cadmium (Cd) concentration in the urine as well as to evaluate which of these lysosomal enzymes may be a more useful biomarker for the monitoring of Cd-induced tubular damage. For this purpose we have used an experimental model in rats chronically exposed...

Journal: :Clinical chemistry 1991
C D Agardh E Agardh A Isaksson B Hultberg

Urinary N-acetyl-beta-glucosaminidase (NAG) and its isoenzymes (NAG A and NAG B) in samples from 87 type 1 diabetic patients and 40 apparently healthy reference subjects were studied with enzyme immunoassays. The diabetic patients had higher concentrations of urinary NAG than did the control subjects (P less than 0.01), but the isoenzyme pattern did not differ. There was a positive correlation ...

2004
Minsub Shim Thomas E. Eling

NAG-1 (nonsteroidal anti-inflammatory drug-activated gene), a member of TGF beta superfamily, is involved in cellular processes such as inflammation, apoptosis/survival, and tumorigenesis and is regulated by p53, Sp1, and Egr-1. In the current study, the regulation of NAG-1 expression in LNCaP human prostate carcinoma cells by TPA (12O-tetradecanoylphorbol-13-acetate) was examined. TPA treatmen...

Journal: :Molecular cancer therapeutics 2008
Minsub Shim Thomas E Eling

NAG-1 (nonsteroidal anti-inflammatory drug-activated gene), a member of the transforming growth factor-beta superfamily, is involved in many cellular processes, such as inflammation, apoptosis/survival, and tumorigenesis. Vitamin E succinate (VES) is the succinate derivative of alpha-tocopherol and has antitumorigenic activity in a variety of cell culture and animal models. In the current study...

Journal: :Journal of immunology 2007
Mark D Mannie Barbara A Clayson Elizabeth J Buskirk Jarret L DeVine Jose J Hernandez Derek J Abbott

The purpose of this study was to assess whether the Ag-targeting activity of cytokine/neuroantigen (NAg) fusion proteins may be associated with mechanisms of tolerance induction. To assess this question, we expressed fusion proteins comprised of a N-terminal cytokine domain and a C-terminal NAg domain. The cytokine domain comprised either rat IL-2 or IL-4, and the NAg domain comprised the domin...

Journal: :Journal of immunology 2009
Mark D Mannie Derek J Abbott J Lori Blanchfield

Cytokine-Ag fusion proteins represent a novel approach for induction of Ag-specific tolerance and may constitute an efficient therapy for autoimmune disease. This study addressed whether a fusion protein containing rat IFN-beta and the encephalitogenic 73-87 determinant of myelin basic protein (i.e., the neuroantigen, or NAg) could prevent or treat experimental autoimmune encephalomyelitis (EAE...

2014
GONGLI YANG QINHUA TAN YONGMEI XIE BIN WEI ZHIXIN CHEN CHENGWEI TANG SHENGBAO LI CHUNHUI WANG

Nonsteroidal anti-inflammatory drug-activated gene-1 (NAG-1), a member of the transforming growth factor β (TGF-β) superfamily, has been demonstrated to possess antitumorigenic and proapoptotic activities in gastric cancer cells. In the present study, the expression of NAG-1 was assessed in human gastric carcinoma, tumor-adjacent normal tissues and normal gastric mucosa, with the aim to investi...

Journal: :The Journal of veterinary medical science 2010
Amnart Poapolathep Saranya Poapolathep Yoshiko Sugita-Konishi Kannika Wongpanit Kenji Machii Yoshinori Itoh Susumu Kumagai

This research was conducted to evaluate the effect of naringenin (NAG) on fate and dispositions of deoxynivalenol (DON) in piglets following intravenous (i.v.) administration. Three piglets (Group 1) were pretreated orally with NAG at a dosage of 25 mg/kg bw, once a day for 3 consecutive days, followed by a single i.v. injection of DON at a dosage of 1 mg/kg bw. The other three piglets (Group 2...

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