Stem cells are considered a valuable cellular resource for tissue replacement therapies in most brain disorders. Stem cells have the ability to self-replicate and diff erentiate into numerous cell types, including neurons, oligodendrocytes and astrocytes. As a result, stem cells have been considered the “holy grail” of modern medical neuroscience. Despite their tremendous therapeutic potential,...

The skin is a complex stratifi ed organ which acts not only as a permeability barrier and defense against external agents, but also has essential thermoregulatory, sensory and metabolic functions. Due to its high versatility and activity, the skin undergoes continuous selfrenewal to repair damaged tissue and replace old cells. Consequently, the skin is a reservoir for adult stem cells of diff e...

The new discoveries, the extraordinary dynamism in human stem cell (SC) research, and the great expectations of the benefi ts in clinical treatment of many diseases are on the edge of unparalleled advances in both: 1) the understanding of basic mechanisms of cell diff erentiation and development and 2) the translation from basic research to new clinical therapies. Human stem cells are obtained ...

The Sonic Hegdehog/GLI (SHH/GLI) pathway has been extensively studied for its role in developmental and cancer biology. During early embryonic development the SHH pathway is involved mainly in pattern formation, while in latter stages its function in stem cell and progenitor proliferation becomes increasingly relevant. During postnatal development and in adult tissues, SHH/GLI promotes cell hom...

Hematopoietic stem cell transplantation is the accepted therapy of choice for a variety of malignant and non-malignant diseases in children and adults. Initially developed as rescue therapy for a patient with cancer after high doses of chemotherapy and radiation as well as the correction of severe defi ciencies in the hematopoietic system, it has evolved into an adoptive immune therapy for mali...

Two highly similar RNA polymerase sigma subunits, σ(F) and σ(G), govern the early and late phases of forespore-specific gene expression during spore differentiation in Bacillus subtilis. σ(F) drives synthesis of σ(G) but the latter only becomes active once engulfment of the forespore by the mother cell is completed, its levels rising quickly due to a positive feedback loop. The mechanisms that ...

Background Alzheimer’s Dementia (AD) is characterized by cognitive and neuropsychiatric symptoms (NPS). Recently, decline in AD has been linked to increased cortical excitability. However, the relationship between NPS excitability remains unclear. This study investigated dorsolateral prefrontal cortex (DLPFC). Method 24 participants with probable diagnosed using National Institute of Aging-Alzh...

This paper defends the Euro from point of view Austrian Economics. Folloming Mises and Hayek it demonstrates is acting as a proxy gold standard disciplining polititians putting limit to growth welfare state. Key words: Gold standard, fixed flexible exchange rates, state crisis, competition among monetary areas, keynesianism, monetarism, School. JEL Classification: N15, N45, O53, P11, X10. Resum...