N-arylpyrrole-based dyes possessing excellent opto-electronic properties are promising candidates for two-photon fluorescence labeling materials. The systematic investigation of novel N-arylpyrrole derivatives is of great importance for both fine-tuning electronic spectra and designing two-photon absorption (2PA) materials. We thoroughly studied influences of the π-conjugated center and N-subst...

(Z,Z)-Muconaldehyde reacted with primary amines to give N-substituted-2(2'-oxoethyl)-pyrroles, which were reduced to N-substituted-2-(2'-hydroxyethyl)-pyrroles by sodium borohydride. The pyrrole-forming reaction is exhibited by valine and its methyl ester, and is being developed with terminal valine in hemoglobin as a means of dose monitoring (Z,Z)-muconaldehyde, a putative metabolite of benzen...

2-Azetidinones and pyrroles are two highly important classes of molecules in organic and medicinal chemistry. A green and practical method for the synthesis of 3-pyrrole-substituted 2-azetidinones using catalytic amounts of molecular iodine under microwave irradiation has been developed. Following this method, a series of 3-pyrrole- substituted 2-azetidinones have been synthesized with a variet...

An efficient synthesis of substituted isocanthines has been achieved using an intramolecular Rh(III)-catalyzed C-H functionalization of alkyne-tethered indoles in the presence of catalytic tris(acetonitrile)pentamethylcyclopentadienylrhodium(III) hexafluoroantimonate and stoichiometric copper(II) acetate. This isocanthine synthesis tolerates a variety of electronically diverse 5- or 6-substitut...

BACKGROUND The classical Paal-Knorr reaction is one of the simplest and most economical methods for the synthesis of biologically important and pharmacologically useful pyrrole derivatives. RESULTS Polystyrenesulfonate-catalyzed simple synthesis of substituted pyrroles following Paal-Knorr reaction has been accomplished with an excellent yield in aqueous solution. This method also produces py...

Yndiamides (bis-N-substituted alkynes) are valuable precursors to azacycles. Here we report a cycloisomerization/1,2-sulfonyl migration of alkynyl-yndiamides form tetrahydropyrrolopyrroles, unprecedented heterocyclic scaffolds that relevant medicinal chemistry. This functional group tolerant transformation can be achieved using Au(I) catalysis proceeds at ambient temperature, and thermally prom...

Substituted pyrroles are an essential class of heterocyclic compounds. In this research, an efficient and eco-friendly method has been developed for the synthesis of pyrrole derivatives from the reaction of 2,5-hexanedione and primary amines. Magnetic nanoparticles supported on functionalized. 7-aminonaphthalene-1,3-disulfonic acid-functionalized. silica (Fe3O4@SiO2@Propyl–ANDSA) has been inves...