نتایج جستجو برای: n butylacetate
تعداد نتایج: 976489 فیلتر نتایج به سال:
It has previously been shown that in most joint diseases changes occur in the hyaluronic acid in the joint fluid. In diseased fluids the hyaluronic acid has a considerably lower degree of polymerization than in normal fluids or in uncomplicated traumatic effusions (Sundblad, 1953). The hyaluronic acid changes are especially marked in rheumatoid arthritis. We recently demonstrated (Sundblad, Ege...
Substitution of hazardous substances against less hazardous ones is a central requirement of the European Chemical Regulation REACH (European Regulation 1907/2006/EC). Hazardous substances emitted from products may not only affect the worker; drift off and distribution in the environment may finally result in exposure of the general population. This potential threat to health is covered by the ...
The incidence of neurophysiological disorders and polyneuropathies has been seen as a consequence of long-term occupational exposure to organic solvents. The aim of the study was to determine, and histologically quantify the changes in the sciatic nerves of the rats intoxicated by inhalation of organic solvents (toluene, xylene, n-butylacetate, acetone and white-spirit) in the concentrations of...
This study revealed the dose dependency of prednisolone tertiary-butylacetate (PTBA) treatment on the establishment of Echinococcus multilocularis in the small intestine of Mongolian gerbil (Meriones unguiculatus) and that some of the physiological parameters of host were correlated with the doses of PTBA and establishment of the worm. Twenty Mongolian gerbils were divided into 5 groups, accord...
Induction of cytochrome P450 3A4 (CYP3A4) is determined typically by employing primary culture of human hepatocytes and measuring CYP3A4 mRNA, protein and microsomal activity. Recently a pregnane X receptor (PXR) reporter gene assay was established to screen CYP3A4 inducers. To evaluate results from the PXR reporter gene assay with those from the aforementioned conventional assays, 14 drugs wer...
Glucocorticoids regulate the rat glutathione S-transferase A2 (GSTA2) gene in a biphasic manner in cultured hepatocytes that repress gene expression at low concentration (10--100 nM) but induce gene expression at high concentration (>1 microM). High concentrations of the glucocorticoid receptor (GR) antagonist RU38486 (5--10 microM) also induced the expression of GSTA2. These effects were repro...
The pregnane X receptor (PXR) is involved in transcriptional regulation of multiple cytochromes P450 and multidrug resistanceassociated protein (MDR1), which encodes for the drug transporter P-glycoprotein. Crystal structure analyses suggest that the ligand binding domain is highly hydrophobic and flexible, allowing molecules of differing sizes to bind in multiple orientations. Using literature...
glucose, 1.0 % peptone, 1.0 % corn steep liquor, 0.2 /00 KH2PO4 and 0.1 % MgSO4 (pH 6.5) for 66 hours at 26°C. Botric acid principally existed in the mycelia, the activity was bio-assayed using Candida albicans as a test organism on SABOURAUD'S glucose medium. The cultured broth (180 liters) was filtered, and the mycelial cake was extracted twice with each 20liters of acetone. The extract was c...
Force field and first principles molecular dynamics simulations on complexes of pig liver esterase (pig liver isoenzymes and a mutant) and selected substrates (1-phenyl-1-ethyl acetate, 1phenyl-2-butylacetate, proline-β-naphthylamide and methyl butyrate) are presented. By restrained force field simulations the access of the substrate to the hidden active site was probed. For a few substrates sp...
Highly efficient method for the preparation of N-tert-butyl amides by reaction of nitriles with tertbutylacetateis described using boron trifluoride etherate in solvent free condition. Selective amidation ofbenzonitrile in the presence of acetonitrile was also achieved.
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