The in vivo metabolism of an antiallergic agent, azelastine, (4-(p-chlorobenzyl)-2-[Nmethylperhydroazepinyl-(4)]-l-(2H)-phthalazinone hydrochloride) was examined following oral administration to rats and guinea pigs. As a result, it was found that the drug was metabolized to 4-(p-chlorobenzyl)-2-[N-methyl-7-oxo-perhydroazepinyl-(4)]l-(2H)-phthalazinone, 6-hydroxy-4-(p-chlorobenzyl)-2-[N-methylp...

a number of 3-amino-1, 2, 4-triazin-5 (2h)- ones(1) were synthesized and condensed with a-haloketones to give 2,6-disubstituted imidazo [1, 2-b] [1, 2, 4]-triazin-3 (4h)-ones (2). these compounds were reacted further with a - haloketones to yield n-alkylated products (3).

utilization of photodisintegration reaction of deuterium, 2h(?,n)1h, is a precise technique for determining the percentage of 2h in tritiated and natural water. the 23na(n,?)24na reaction is a suitable ?-source for producing the 2h(?,n)1h reaction. tehran research reactor was used as a neutron source for producing 24na isotopes. the bf3 detectors were used to detect the neutron emission of h2 c...

Reaction of tryptamine 1 with dimethyl -3-methoxyallylidenemalonate 2 afforded N?-[4,4-bis (methoxycarbonyl)-1,3-butadienyl] tryptamine 3 which in combination with acetylchloride and pyridine in dichloromethane gave N?, N?-[acetyl]-[(4,4-dinethoxycarbonyl) 1,3butadienyl] tryptamine 4. Treatment of 3 with sodium hydroxide afforded 2H[N-(3-indolyl) ethyl] 2-oxo-3-methoxycarbonyl-1-pyridine 5. Cy...

Utilization of Photodisintegration reaction of Deuterium, 2H(?,n)1H, is a precise technique for determining the percentage of 2H in tritiated and natural water. The 23Na(n,?)24Na reaction is a suitable ?-source for producing the 2H(?,n)1H reaction. Tehran Research Reactor was used as a neutron source for producing 24Na isotopes. The BF3 detectors were used to detect the neutron emission of H2 c...

Three coumarin derivatives, viz. 6-methyl-N-(3-methyl-phen-yl)-2-oxo-2H-chromene-3-carboxamide, C18H15NO3 (1), N-(3-meth-oxy-phen-yl)-6-methyl-2-oxo-2H-chromene-3-carboxamide, C18H15NO4 (2), and 6-meth-oxy-N-(3-meth-oxy-phen-yl)-2-oxo-2H-chromene-3-carboxamide, C18H15NO5 (3), were synthesized and structurally characterized. The mol-ecules display intra-molecular N-H⋯O and weak C-H⋯O hydrogen bo...

A number of 3-amino-1, 2, 4-triazin-5 (2H)- ones(1) were synthesized and condensed with a-haloketones to give 2,6-disubstituted imidazo [1, 2-b] [1, 2, 4]-triazin-3 (4H)-ones (2). These compounds were reacted further with a - haloketones to yield N-alkylated products (3).

reaction of tryptamine 1 with dimethyl -3-methoxyallylidenemalonate 2 afforded n?-[4,4-bis (methoxycarbonyl)-1,3-butadienyl] tryptamine 3 which in combination with acetylchloride and pyridine in dichloromethane gave n?, n?-[acetyl]-[(4,4-dinethoxycarbonyl) 1,3butadienyl] tryptamine 4. treatment of 3 with sodium hydroxide afforded 2h[n-(3-indolyl) ethyl] 2-oxo-3-methoxycarbonyl-1-pyridine 5. cyc...

We prepared a novel fluorous deoxy-fluorination reagent N,N-diethyl--difluoro-[3,5-bis(1H,1H,2H,2H-perfluorodecyl)benzyl]amine (1b) from 3,5-diiodobenzoic acid (3b) via N,N-diethyl-3,5-bis(1H,1H,2H,2H-perfluorodecyl)benzamide (2b) in four steps and used it for the fluorination of alcohols and diols. After the fluorination reactions, the isolation of the products and recovery of 2b was perfor...