نتایج جستجو برای: myocardial ischemia reperfusion

تعداد نتایج: 215814  

Journal: :iranian journal of medical sciences 0
gino a. kurian j. paddikkala

background: calcium overload and free radical mediated damage in the mitochondria is the most important pathological changes associated with myocardial ischemic-reperfusion injury. the verapamil post-treatment has been previously reported to prevent reperfusion-induced myocardial injury but functional recovery may be delayed due to the drug's inherent direct myocardial depression effect. in the...

In the current study, effects of acute short term administration of fructose on cardiac arrhythmias and myocardial infarction size following ischemia/reperfusion were investigated in isolated rat heart. The hearts were subjected to 30 min zero flow global ischemia followed by 120 min reperfusion. In the control group, the hearts were perfused by normal drug free Krebs-Henseleit (K/H) solution t...

Journal: :iranian journal of basic medical sciences 0
moslem najafi department of pharmacology, school of pharmacy, research center for pharmaceutical nanotechnology, tabriz university of medical sciences, tabriz, iran saba ghaffary department of pharmacology, school of pharmacy, tabriz university of medical sciences, tabriz, iran elnaz shaseb department of pharmacology, school of pharmacy, tabriz university of medical sciences, tabriz, iran

objective(s) this study aimed to examine whether acetyl-l-carnitine (alc) was able to reduce cardiac arrhythmias and infarct size in the ischemic-reperfused isolated rat heart. materials and methods the isolated hearts were mounted on a langendorff apparatus then perfused by a modified krebs-henseleit solution during 30 min regional ischemia and 120 min reperfusion (control) or by enriched kreb...

Journal: :avicenna journal of phytomedicine 0
najmeh sadeghi department of physiology, faculty of medicine, jahrom university of medical sciences, jahrom, iran mahin dianat physiology research center, department of physiology, faculty of medicine, ahvaz jundishapur university of medical sciences, ahvaz, iran mohammad badavi physiology research center, department of physiology, faculty of medicine, ahvaz jundishapur university of medical sciences, ahvaz, iran ahad malekzadeh department of statistic, khajeh nasir toosi university of technology, tehran, iran

objective: several studies have shown that chichorium intybus l. (c. intybus) which possesses flavonoid compounds has an effective role in treatment of cardiovascular diseases. contractile dysfunction mostly occurs after acute myocardial infarction, cardiac bypass surgery, heart transplantation and coronary angioplasty. the aim of the present study was to investigate the effect of aqueous extra...

Journal: :Circulation research 2007
John W Calvert Susheel Gundewar Munekazu Yamakuchi Pierce C Park William M Baldwin David J Lefer Charles J Lowenstein

Exocytosis of endothelial granules promotes thrombosis and inflammation and may contribute to the pathophysiology of early reperfusion injury following myocardial ischemia. TAT-NSF700 is a novel peptide that reduces endothelial exocytosis by inhibiting the ATPase activity and disassembly activity of N-ethylmaleimide-sensitive factor (NSF), a critical component of the exocytic machinery. We hypo...

In the current study, effects of acute short term administration of fructose on cardiac arrhythmias and myocardial infarction size following ischemia/reperfusion were investigated in isolated rat heart. The hearts were subjected to 30 min zero flow global ischemia followed by 120 min reperfusion. In the control group, the hearts were perfused by normal drug free Krebs-Henseleit (K/H) solution t...

Journal: :iranian red crescent medical journal 0
mohammad badavi physiology research centre, department of physiology, faculty of medicine, ahvaz jundishapur university of medical sciences, ahvaz, ir iran; atherosclerosis research center, golestan hospital, ahvaz jundishapur university of medical sciences, ahvaz, ir iran najmeh sadeghi diabetes research center, department of physiology, faculty of medicine, ahvaz jundishapur university of medical sciences, ahvaz, ir iran; diabetes research center, department of physiology, faculty of medicine, ahvaz jundishapur university of medical sciences, ahvaz, ir iran. tel: +98-9177391953 mahin dianat atherosclerosis research center, golestan hospital, ahvaz jundishapur university of medical sciences, ahvaz, ir iran alireza samarbafzadeh infectious and tropical diseases research center, department of virology, faculty of medicine, ahvaz jundishapur university of medical sciences, ahvaz, ir iran

conclusions gallic acid and csa combination improved antioxidant capacity and cell membrane integrity more than each one alone. therefore, it can be a therapeutic approach to reduce the i/r injury. background myocardial infarction is one of the important causes of death during old ages. gallic acid as an antioxidant or cyclosporine a (csa) as inhibitor of mitochondrial permeability transition p...

Introduction: Numerous studies have shown that enriched plasma protects myocardial cells against ischemia. The aim of this study was to evaluate the effect of rat enriched plasma by preconditioning, ischemia, and reperfusion on the differentiation of bone marrow mesenchymal stem cells (BMMSC) into cardiomyocytes. Methods: In this experimental and laboratory study, BMMSCs were extracted from th...

2017
Suli Zhang Jin Wang Yunhui Du Jianyu Shang Li Wang Jie Wang Ke Wang Kehua Bai Tingting Lv Xiao Li Huirong Liu

Ischemic heart disease is a clinical syndrome resulting from myocardial ischemia and is characterized by an imbalance between the supply and demand of myocardial blood flow and myocardial oxygen metabolism. It is currently one of the major diseases that endanger human health. Early and effective reconstruction of ischemic myocardial blood perfusion is the fundamental measure taken to prevent th...

2010
Arun K. Singhal J. David Symons Sihem Boudina Bharat Jaishy Yan-Ting Shiu

Minimizing myocardial ischemia-reperfusion injury has broad clinical implications and is a critical mediator of cardiac surgical outcomes. "Ischemic injury" results from a restriction in blood supply leading to a mismatch between oxygen supply and demand of a sufficient intensity and/or duration that leads to cell necrosis, whereas ischemia-reperfusion injury occurs when blood supply is restore...

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