Multiple myeloma is a monoclonal malignant proliferation of plasma cells. The disease is more frequent in men, and the average age of patients at the time of diagnosis of the disease is about 60 years. Solitary myeloma may be the first manifestation of the disseminated form of multiple myeloma, which is characterized by multiple skeletal lesions, general metabolic alterations, impairment of ren...

Background: Epigenetic modifications, such as methylation can occur in multiple myeloma. SMG1is an important gene involved in cell growth which defect in methylation of its promoter leads to reduction of cell apoptosis and uncontrolled proliferation. In this study, we identified the methylation status of the SMG1 gene promoter in patients with multiple myeloma. Methods: Methylation status of S...

objective: multiple myeloma (mm) is a plasma cell malignancy where plasma cells are increased in the bone marrow (bm) and usually do not enter peripheral blood, but produce harmful factors creating problems in these patients (e.g. malignant plasma cells over activate osteoclasts and inhibit osteoblasts with factors like rankl and dkk). these factors are a main cause of bone lesion in mm patient...

introduction plasma cell dyscrasias are characterized by a monoclonal neoplastic proliferation of plasma cells. solitary bone plasmacytoma (sbp) is a local form of the disease with the vertebrae and long bones being the most frequently encountered sites. its prevalence in the maxillofacial area is extremely rare. case presentation a 70-year-old caucasian male patient was referred for the extrac...

chronic myelogenous leukemia (cml) is a stem cell disorder sometimes associated with lymphoproliferative disorders. cml may precede a lymphoproliferative disorder. there are a few reports showing associating of cml with multiple myeloma and we report a known cml case that transformed into a full-blown multiple myeloma. this patient had more than 69% of infiltrating myeloma cells in her bone mar...

multiple myeloma is a monoclonal malignant proliferation of plasma cells. the disease is more frequent in men, and the average age of patients at the time of diagnosis of the disease is about 60 years. solitary myeloma may be the first manifestation of the disseminated form of multiple myeloma, which is characterized by multiple skeletal lesions, general metabolic alterations, impairment of ren...

A 54 year old man with history of cardiomyopathy and chronic fibrillation first presented with bloody diarrhea. Then during the assessment of his abnormal lab. data revealed cast nephropathy in renal biopsy, gamma peak in protein electrophoresis and fine lytic lesions in skull graphy. His bone marrow asp...

multiple myeloma is a neoplastic plasma cell dyscrasia. patients usually present with bone pain, anemia, hypercalcemia and renal failure. unusual presentations include progressive bilateral carpal tunnel syndrome, polyarthritis, amyloidosis of the tongue, and involvement of pulmonary parenchyma. early diagnosis is important for timely therapy. we present the case of a patient with clinical feat...

Multiple myeloma is one of the most commonly diagnosed blood cancers. Due to introduction new therapies in recent years, there has been significant progress treating myeloma. Even so, with groups drugs, have some adverse events. In addition anti-myeloma treatment, patients require supportive therapies. This article presents principles treatment emergencies and discusses toxicity associated use ...