a spectrophotometric method for selective complexation reaction and simultaneous determination of mycophenolate mofetil (mpm), and mycophenolic acid (mpa) using three multivariate chemometric methods, i.e. partial least squares regression, principal component regression and principal component artificial neural networks, is proposed. the method is based on the complexation reaction of mpm and m...

mycophenolic acid is a secondary extracellular metabolite of penicillium strains with numerous pharmaceutical properties such as antibiotic and immunosuppressive uses. the aim of this work is the survey of the effect of phenylglyoxal and n-ethylmaleimide concentration in culture medium on mycophenolic acid production by penicillium brevi-compactum atcc16024 was investigated. batch submerged fer...

objectivemycophenolate mofetil (mmf) is commonly administered concomitantly with ganciclovir for managingtransplant recipients who infected with cmv. this study was conducted to evaluate the probable effects ofganciclovir on mycophenolic acid (mpa) pharmacokinetic.materials and methodsten kidney transplant recipients who full field inclusion and exclusion criterias enrolled in this study. thefi...

The introduction of the immunosuppressive agent mycophenolate mofetil as a standard-dose drug has resulted in a reduced risk of rejection after renal transplantation and improved graft survival compared to azathioprine. The favorable balance between efficacy and safety has made mycophenolate mofetil a cornerstone immunosuppressive drug, and the vast majority of newly transplanted patients are n...

The final step in the biosynthesis of mycophenolic acid involves the transfer of a methyl group from S-adenosylmethionine to demethylmycophenolic acid. The enzyme, S-adenosylmethionine:demethylmycophenolic acid O-methyltransferase, was isolated from Penicillium stoloniferum and purified 2,700-fold by ammonium sulfate fractionation and diethylaminoethyl-cellulose and Sephadex G-200 chromatograph...

Mycophenolic acid (MPA) is an antibiotic and immunosuppressive drug produced by Penicillium strains as a secondary extracellular metabolite. In this work, the effect of some various concentrations of enzymatically hydrolyzed casein on mycophenolic acid yield and process productivity was studied. The first, a base medium was applied for mycophenolic acid production by Penicillium brevicompactum ...

Based on their study, “Increased mycophenolic acid exposure in stable kidney transplant recipients on tacrolimus as compared with , Braun et al. concluded that mycophenolic acid (MPA) exposure is greater in those on sirolimus: implication for pharmacokinetics ” tacrolimus treated patients than in those treated with sirolimus during maintenance immunosuppression after kidney transplant and sugge...

The possibility that purine inhibitors or analogs might be effective antileishmanial agents led to the determination of the antileishmanial activity of mycophenolic acid and allopurinol in vitro. The drugs were tested against Leishmania tropica amastigotes (mammalian forms) within human macrophages, a model in which achievable serum concentrations of antileishmanial agents currently in use elim...