BACKGROUND Out of 3 billion base pairs in human genome only ~2% code for proteins; and out of 180,000 transcripts in human cells, about 20,000 code for protein, remaining 160,000 are non-coding transcripts. Most of these transcripts are more than 200 base pairs and constitute a group of long non-coding RNA (lncRNA). Many of the lncRNA have its own promoter, and are well conserved in mammals. Ac...

Submit Manuscript | http://medcraveonline.com Abbreviations: ncRNAs: Noncoding RNAs; miRs: MicroRNAs; lncRNAs: Long noncoding RNAs; RISC: RNA-Induced-SilencingComplex; mRNAs: Messenger RNAs; CLL: Chronic Lymphocytic Leukemia; RREB1: Ras-Responsive Element-Binding Protein 1; HK2: Hexokinase 2; AldoA: Aldolase A; GPD2: Glycerol-3-phosphate dehydrogenase-2; Xist: X Inactive Specific Transcript; XC...