Abstract. We generalize earlier results of [2], [3], [6], [13], [14] to the case of functions of n-tuples of commuting self-adjoint operators. In particular, we prove that if a function f belongs to the Besov space B ∞,1(R ), then f is operator Lipschitz and we show that if f satisfies a Hölder condition of order α, then ‖f(A1 · · · , An)− f(B1, · · · , Bn)‖ ≤ constmax1≤j≤n ‖Aj −Bj‖ α for all n...