نتایج جستجو برای: mutagenicity tests
تعداد نتایج: 339246 فیلتر نتایج به سال:
For biodetection of mutagenic pollution of marine environments, an organism naturally occurring in these habitats should be used. We found that marine bacterium Vibrio harveyi may be an appropriate bioindicator of mutagenic pollution. For positive selection of mutants, we developed a simple method for isolation of V. harveyi mutants resistant to neomycin. We constructed genetically modified V. ...
I would like to focus attention first on three major and immediate problem areas inherent in any testing system and then to discuss to a limited extent a major problem, generally not discussed, involved in the elucidation of the meaningfulness of any test system for human health and welfare. The three problem areas I wish to discuss first are: (1) the toxic agent-the suspect compound; (2) the t...
In this study, we investigated the applicability of using in vivo mouse micronucleus (MN) data to derive cancer potency information. We also present a new statistical methodology for correlating estimated potencies between in vivo MN tests and cancer studies, which could similarly be used for other systems (e.g. in vitro vs. in vivo genotoxicity tests). The dose-response modelling program PROAS...
At the request of the European Food Safety Authority, the Scientific Committee has reviewed the 8 current state-of-the-science on genotoxicity testing strategies and provided a commentary and 9 recommendations on testing strategies, bearing in mind the needs of EFSA’s various Scientific Panels 10 to have appropriate data for risk assessment. It is hoped that this opinion will contribute to grea...
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