MicroRNAs (miRNAs) play crucial roles in the establishment of pluripotent state by controlling pluripotent network. However, the molecular mechanisms controlling miRNAs during somatic cell reprogramming remain obscure. In this study, we show Gadd45a (growth arrest and DNA-damage-inducible protein 45a) enhances reprogramming by activating miR-295. Furthermore, we show that Gadd45a binds the prom...

A Gram-negative, rod-shaped bacterium (designated strain UST030701-295(T)) with fast gliding motility was isolated from the surface of the sponge Lissodendoryx isodictyalis in the Bahamas. Colonies of UST030701-295(T) were yellow in colour, 2-4 mm in diameter, convex with a smooth surface and entire margins. UST030701-295(T) was heterotrophic, strictly aerobic and required NaCl for growth (1.0-...

MicroRNAs, 22nt long RNAs derived from hairpin transcripts, are important regulators of gene expression and have been shown to participate in regulation of every biological process known to date. Mir-290 through mir-295 (mir-290-295) is a mammalian-specific miRNA cluster that, in the mouse, is expressed specifically in early embryos and embryonic germ cells. This thesis examines the in vivo con...

BACKGROUND Mobile phones have become nearly ubiquitous, offering a promising means to deliver health interventions. However, little is known about smartphone applications (apps) for cancer. OBJECTIVE The purpose of this study was to characterize the purpose and content of cancer-focused smartphone apps available for use by the general public and the evidence on their utility or effectiveness....

http://www.sciencemag.org/cgi/content/full/295/5563/2279 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/295/5563/2279/DC1 can be found at: Supporting Online Material found at: can be related to this article A list of selected additional articles on the Science Web sites http:/...

http://www.sciencemag.org/cgi/content/full/295/5563/2267 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/295/5563/2267/DC1 can be found at: Supporting Online Material found at: can be related to this article A list of selected additional articles on the Science Web sites http:/...

C.Dechanet1,, T. Anahory1, J.C.Mathieu Daude2, X.Quantin3, L. Reyftmann1, S.Hamamah1, B. Hedon1, and H.Dechaud1 Department of Medicine and Biology of Reproduction, Hôpital Arnaud de Villeneuve, 371 Avenue du Doyen Gaston Giraud, 34 295 Montpellier Cedex 5, France Department of Toxicology, Hôpital Lapeyronie, 371 Avenue du Doyen Gaston Giraud, 34 295 Montpellier Cedex 5, France Department of Tho...

Bacterioplankton abundance and metabolic characteristics were observed in northern San Francisco Bay, California, during spring and summer 1996 at three sites: Central Bay, Suisun Bay, and the Sacramento River. These sites spanned a salinity gradient from marine to freshwater, and sampling occurred during a period of seasonally declining river flow. The microbial measures included radio-labeled...