Spinal cord injury (SCI) is a neurologic disorder that have a significant impact on quality of life, life expectancy, and economic burden. SCI leads to irreversible neuronal loss and ultimately leads to paralysis. Mesenchymal stem cells (MSCs) are a promising source for cellular therapy because they have possessed the capacity of self-renewal and differentiation to several distinct mesenchymal ...

The identification of multipotential mesenchymal stem cells (MSCs) derived from adult human tissues such as bone marrow and connective tissues has provided exciting prospects for cell-based tissue engineering and regeneration. This review article focuses on the biology of MSCs, their differentiation potentials in vitro and in vivo, and their application in tissue engineering...

Background and Objective: Mesenchymal stem cells (MSCs) promote metastasis in colorectal cancer; however, the mechanism underlying this process is not fully understood. Epithelial to mesenchymal transition (EMT) is a key step in tumor acquisition of metastatic phenotype. We aimed to investigate the effect of MSCs on the expression of EMT markers, as well as cancer stem cell markers in HT-29 col...

background: mesenchymal stem cells (mscs) are multipotential cells and their therapeutic potency is under intense investigation. studying the effect of different induction factors on mscs could increase our knowledge about the differentiation potency of these cells. one of the most important sources of these factors in mammalian body is platelet. platelet lysate (pl) contains many growth factor...

Osteophytes are a distinct feature of osteoarthritis (OA). Their formation may be related to pluripotential cells in the periosteum responding to stimulus during OA. This study aimed to isolate stem cells from osteophyte tissues and to characterize their phenotype, proliferation, and differentiation potential, as well as their immunomodulatory properties. Osteophyte-derived cells were isolated ...

conclusions although the aforementioned challenges must still be addressed, the potential of wjmscs in skin regenerative clinical treatments is promising. results similar to bone marrow mscs, wjmscs express major histocompatibility complex (mhc) class i molecules. evidence acquisition according to research conducted by various researchers, wharton’s jelly mesenchymal stem cells (wjmscs) have se...

Osteonecrosis of the femoral head (ONFH) is a type of common and refractory disease in the orthopedic clinic that is primarily caused by a partial obstruction of the blood supply to the femoral head, resulting in a series of pathological processes. Mesenchymal stem cells (MSCs) comprise a mixture of various stem cells in myeloid tissue with multipotential differentiation capacity. They can diff...

mesenchymal stem cells (mscs) could differentiate into various types of tissues. these cells serve as a backup for the regeneration and repair of tissues or cells after injury. a skin wound is defined as an injury to the skin that needs to be restored. all types of cells in skin especially mesenchymal stem cells play important role in wound healing process. in particular, paracrine signaling of...