The odontogenic fibroma is a rare, benign tumor of mesodermal origin, and one of the most ill-defined and least understood of all odontogenic neoplasms. 1 It presently is thought to originate from either dental follicle, periodontal ligament, or dental papilla. 2 Bhaskar reported the lesion as being the most common odontogenic tumor comprising approximately 23°70 of all odontogenic lesions. 3 T...

Two cases of calcifying cystic odontogenic tumor (CCOT) of the dental follicle in an impacted third molar without clinical and radiological evidence are reported during routine histopathological examination. In both the cases left mandibular third molar was mesioangularly impacted with pericoronal radiolucency of less than 2.5 mm, which was not indicative of any pathology. As a routine protocol...

In this study, we compared the gene expression profiles of non-syndromic hyperplastic dental follicle (HDF) fibroblasts and normal dental follicle (NDF) fibroblasts using cDNA microarrays, quantitative PCR, and immunohistochemical staining. Microarray analysis showed that several collagens genes were upregulated in the HDFos, including collagen types I, IV, VIII, and XI and TIMP-1, -3, and -4 (...

Calcifying epithelial odontogenic tumors are rare odontogenic neoplasms that account for approximately one percent of all odontogenic tumors. Extra osseous variant is very rare with very few cases being reported in literature Peripheral Calcifying epithelial odontogenic tumor (CEOT) commonly resemble oral hyperplastic or reactive lesions and are histologically similar to their intraosseous coun...

Multiple calcified hyperplastic dental follicles (MCHDF) are an extremely rare condition which has been categorized as a separate pathological entity very recently. It was initially described by Sandler et al. Gardner and Radden proposed this as a separate pathological entity. This disease is characterized by multiple unerupted teeth with abundant calcifications and rests of odontogenic epithel...