The search for novel photoprotective substances has become a challenge in cosmeceutical research. Streptomyces-derived compounds can serve as promising source of agents to formulate skin photoprotection products, such sunscreens. This study aimed identify specialized metabolites with the potential modulate UV-induced cellular damage by identifying multi-target-directed ligands. Using combinatio...

Alzheimer's disease (AD) is a complex neurodegenerative disorder involving multiple cellular and molecular processes. The discovery of drug molecules capable of targeting multiple factors involved in AD pathogenesis would greatly facilitate in improving therapeutic strategies. The repositioning of existing non-toxic drugs could dramatically reduce the time and costs involved in developmental an...

Evodiamine, a naturally occurring indole alkaloid, is one of the main bioactive ingredients of Evodiae fructus. With respect to the pharmacological actions of evodiamine, more attention has been paid to beneficial effects in insults involving cancer, obesity, nociception, inflammation, cardiovascular diseases, Alzheimer's disease, infectious diseases and thermo-regulative effects. Evodiamine ha...

BACKGROUND According to Cobanoglu et al., it is now widely acknowledged that the single target paradigm (one protein/target, one disease, one drug) that has been the dominant premise in drug development in the recent past is untenable. More often than not, a drug-like compound (ligand) can be promiscuous - it can interact with more than one target protein. In recent years, in in silico target p...