Nickel(0) catalysts were used to produce substituted imidazoles in good to high yields using benzonitrile, p-substituted benzonitriles and 4-cyanopyridine as starting materials.

Anthelmintic resistance creates a major hitch over the decades throughout the world. As per WHO only few drugs are frequently used in the treatment of helminth infestations in human beings. In view of this, an attempt has been made to study the anthelmintic activity of some newly synthesized 1-substituted imidazoles (1a-1d, 2a-2d) were synthesized and characterized by their spectral data. All t...

Substituted imidazoles are of interest because their useful biological activities. While several methods have been developed for the synthesis such compounds, some reported utilize corrosive or toxic catalysts. We report a bismuth (III) triflate catalyzed multicomponent 2,4,5-trisubstituted imidazoles. Bismuth compounds attractive from green chemistry perspective they remarkably non-toxic and n...

[reaction: see text] A simple, high-yielding synthesis of 2,4,5-trisubstituted imidazoles from 1,2-diketones and aldehydes in the presence of NH(4)OAc is described. Under microwave irradiation, alkyl-, aryl-, and heteroaryl-substituted imidazoles are formed in yields ranging from 80 to 99%. Short syntheses of lepidiline B and trifenagrel illustrate the utility of this approach.

A one-pot, two step synthesis of highly substituted imidazoles has been carried out in good to excellent yields for the first time via a cascade intermolecular aza-SN2'-intramolecular aza-Michael addition involving a variety of Morita-Baylis-Hillman acetates of nitroalkenes and amidines in the presence of DABCO at room temperature. The synthetic and biological utility of the products has been d...

warded as a promising molecule because of its broad spectrum pharmacological activities like antitubercular, antibacterial, antifungal, anticancer, anti-HIV, anthelmintic, anti-inflammatory and antihypertensive activities. Imidazoles are one of the oldest and potent heterocyclic compounds having antimicrobial activities. Structure activity relationship studies of quinazolinone ring system revea...

Starting from commercially available amines and propargylamides a variety of substituted imidazoles were synthesized via a novel hydroamination-cyclization sequence. The target compounds are obtained in good to excellent yields in the presence of catalytic amounts of zinc triflate.

A short and efficient synthesis of 1,4-disubstituted imidazoles has been developed which provides the desired products with complete regioselectivity. This protocol allows preparation of compounds which are challenging to prepare by current literature methods in a regioselective fashion, a sterically and electronically diverse range of N-substituents being accessible. The sequence involves an u...

The microwave assisted and solvent free synthesis of title compounds is described in this protocol. Ten new aryl imidazoles, which are incorporated with the chemotherapeutic pharmacophores, have been synthesized by adopting one pot multicomponent reaction. First, primary aromatic or heteryl amine has been condensed with aryl or heteryl aldehydes to afford corresponding Schiff base. The Schiff b...