objective(s):   the ongoing increasing antibiotic resistance is one of the biggest challenges faced by global public health. the perennial need for new antimicrobials against a background of increasing antibiotic resistance in pathogenic and opportunistic microorganisms obliges the scientific community to constantly develop new drugs and antimicrobial agents. lichens are known prolific sources ...

purpose: the aim of the present study was to detect the expression of p-glycoprotein (p-gp) and multi-drug resistance associated protein 1 (mrp1) in retinoblastoma tumors, and analyze the relationship between its expression, the clinico-pathological features and recurrence. methods: p-gp and mrp1 expression in formalin-fixed paraffin-embedded retinoblastoma bearing ocular tissue sections from 2...

background: chemotherapy plays a very important role in the treatment of leukemia but the resistance properties of the lymphoblasts limit the effect of chemotherapy. one of the main mechanisms of resistance to chemotherapy is the increased expression of mdr1 gene. the aim of this study was to explore the effect of resveratrol on the expression of mdr1 gene in leukemic lymphoblast of new cases o...

antibiotic resistance of pseudomonas aeruginosa remains a major problem in burn patients. the main objective of this study was to determine the antibiotic resistance pattern and frequency of class 1 integrons among p. aeruginosa strains isolated from patients with burn wound infections in a new burn centre in guilan, iran.the bacterial isolates were collected from 182 patients with burn wound i...

conclusions this study detected multiple drug resistance (mdr) in p. aeruginosa including aminoglycosides. therefore, identification of drug resistance patterns in p. aeruginosa is of great importance in prevention and control of infections in burn patient centers. background the prevalence of resistance to aminoglycosides among p. aeruginosa isolates has increased all around the world. the res...