the one-pot, multi-component synthesis of 4,4′-(arylmethylene)bis(1h-pyrazol-5-ols) by tandem knoevenagel-michael reaction of phenylhydrazine, ethyl acetoacetate and aldehydes in the presence of silica-bonded n-propylpiperazine sulfamic acid (sbppsa) as a recyclable solid acid catalyst was reported. sbppsa showed much the same efficiency when used in consecutive reaction runs.

A novel, convenient and efficient multi-component reaction for synthesis of phosphonate derivatives from activated acetylenic compounds with 2-hydroxyacetophenone in the presence of phosphites in water lead to the formation of phosphonates in good yields.

In this work, the efficiency, generality and applicability of new Bronsted acidic ionic liquid (BAIL) 1-methyl-3-(2-(sulfooxy)ethyl)-1H-imidazol-3-ium chloride {[Msei]Cl} as heterogeneous and green catalyst for organic transformations are studied. Herein, the following one-pot multi-component reactions in the presence of [Msei]Cl are investigated: (i) the synthesis of quinoxaline derivatives fr...

in this work, the efficiency, generality and applicability of new bronsted acidic ionic liquid (bail) 1-methyl-3-(2-(sulfooxy)ethyl)-1h-imidazol-3-ium chloride {[msei]cl} as heterogeneous and green catalyst for organic transformations are studied. herein, the following one-pot multi-component reactions in the presence of [msei]cl are investigated: (i) the synthesis of quinoxaline derivatives fr...

Three-component reactions have emerged as useful methods because the combinationof three components to generate new products in a single step is extremely economical,among the multi-component reactions. A green, simple, efficient, and cost-effective procedure has been carried out by the synthesis of dihydropyrimidinonesin Biginelli’s condensation of ethyl cyanoacetate, aldehyde and urea or thio...

A water-accelerated multi-component synthesis of organic target molecules was used as a key method for the preparation of cyclopentadiene derivatives. The three-component condensation reactions of primary amines with alkyl propiolates in the presence of N-methylimidazole in water at room temperature were developed as efficient and clean green synthetic procedures for the high-yielding preparati...

One of the important Multi-component reaction (MCRs) is the synthesis of dihydropyrano chromene derivatives by one-pot reaction. In this research, an inexpensive and effective one pot three component procedure with good yields for the synthesis of dihydro pyrano chromenes is reported. In this method, the synthesis of pyrano chromene derivatives was followed by using 4-hydroxycoumarin, malononit...

An efficient one pot multi component synthesis of 1, 4-Polyhydroquinoline derivatives through unsymmetrical Hantzsch reaction using lanthanum chloride heptahydrate (LaCl3.7H2O) from an aromatic aldehyde, ethyl acetoacetate, dimedone and ammonium acetate as a nitrogen precursor in ethanol at room temperature is described. In the present work we report lanthanum chloride heptahydrate remarkably n...

The synthesis of heat integrated multi-component distillation systems is complex due to its huge search space for structural combination and optimization computation. To provide a systematic approach and tools for the synthesis design of distillation systems, a new method for modeling heat integrated columns is presented, and the operating cost objective function is minimized by improved harmon...