A multilayered hydrogel film system based on hyaluronic acid-cysteamine (HA-Cym) and polyvinylalcohol (PVA) was fabricated. It contained a drug-impermeable backing layer, a supporting layer preventing direct contact between the loaded drug and the backing layer, a drug-loading layer and a mucoadhesive layer. Scanning electron microscopy demonstrated the presence of the distinct layers. The comp...

Since last three decades delivery of the desired drug as muocoadhesive drug delivery systems has been subject of interest. Mucoadhesion involving a polymeric drug delivery system is a complex phenomenon that includes theory of diffusion, wetting, adsorption, fracture and interpenetration of polymer chains amongst various other processes. Various polymer-based properties such as the degree of cr...

A novel mucoadhesive buccal tablet containing flurbiprofen (FLB) and lidocaine HCl (LID) was prepared to relieve dental pain. Tablet formulations (F1-F9) were prepared using variable quantities of mucoadhesive agents, hydroxypropyl methyl cellulose (HPMC) and sodium alginate (SA). The formulations were evaluated for their physicochemical properties, mucoadhesive strength and mucoadhesion time, ...

Bioadhesion can be defined as the process by which a natural or a synthetic polymer can adhere to a biological substrate. When the biological substrate is a mucosal layer then the phenomena is known as mucoadhesion. The substrate possessing bioadhesive property can help in devising a delivery system capable of delivering a bioactive agent for a prolonged period of time at a specific delivery si...

Mucoadhesion is a newstrategy to prolong the residence time of various drugs. The capability to adhere to the mucus gel layer which covers the epithelial tissues makes such mucoadhesive polymers very useful excipients in drug delivery.The oral mucosa is highly perfused with blood vessels, hence therapeutic concentrations of the drug can be achieved rapidly. Mucoadhesion is known to increase the...

BACKGROUND Mucoadhesion enables localization of drugs to a defined region of the gastrointestinal tract through attractive interactions between polymers composing the drug delivery devices and the mucin layer of the intestinal epithelium. Thus, this approach can be used for enhancement of the oral bioavailability of the drug. OBJECTIVES The current communication deals with the development of ...

Mucoadhesive polymers have recently gained interest among pharmaceutical scientists as a means of improving drug delivery by promoting dosage form residence time and contact time with the mucous membranes. Mucoadhesion occurs between two surfaces, one of which is a mucous membrane and another is drug delivery system. Pharmaceutical aspects of mucoadhesion have been the subject of great interest...

in order to formulate an efficient and durable mucoadhesive drug delivery system, careful consideration of formulation-related parameters is critical. this study was conducted to investigate the effect of the presence of various types and concentrations of surfactants within or outside carbopol 934 (c934) as well as hydroxypropylmethyl cellulose (hpmc) solid compacts, on their duration of mucoa...