objective: to evaluate the plasma creatine phosphokinase (cpk) level after injection of methotrexate (mtx) as a predictor of treatment success in ectopic pregnancy (ep). materials and methods: one hundred women treated with single dose of methotrexate for ectopic pregnancy were evaluated in a prospective study, for cpk and ß-subunit of human chorionic gonadotropin (ß-hcg) levels. they received ...

The efficacy of methotrexate (MTX) as an antimetabolite chemotherapeutic agent highly depends on its blood circulation half-life. In our previous study, different conjugates of MTX (MTX-PEG) were synthesized, their physicochemical properties were investigated and MTX-PEG5000 was finally selected as optimum drug-conjugate for further investigations. In the current work, first the stability of MT...

current study was aimed to evaluating protective effects of cornus mas fruit extract (cmfe) in mice treated with methotrexate (mtx). for this purpose, 48 young mature male mice were divided into 6 groups. control group received only normal saline (0.1 mlper day, intraperitoneally), and the second group was administered mtx (20 mg kg-1 perweek, intraperitoneally). the third, fourth and fifth gro...

background: methotrexate has an important role in treatment of acute leukemia. we measured methotrexate level in csf and blood of children with acute lymphoblastic leukemia to determine complications and outcomes. materials and methods: one hundred and twenty patients (73 male, 47 female), with mean age at diagnosis of 6.1 years (11mo_15years) entered the study. patients were divided into two g...

Abstact：objective To investigate acute kidney injury (AKI) in children with acute lymphoblastic leukemia (ALL) who received high dose methotrexate (MTX) chemotherapy and explore the corresponding treatment. Methods 180 children who received high dose MTX chemotherapy were observed with serum MTX concentration and serum creatinine. Patients with AKI of stage 3 or poor response to conventional tr...

background and aims: methotrexate (mtx), a folic acid antagonist, is widely used as a treatment for malignancies as well as in the treatment of various inflammatory and autoimmune disorders. nephrotoxicity is an important side-effect of this drug. prevention and treatment of mtx-induced renal dysfunction are essential to prevent potentially life-threatening mtx-associated toxicities, present st...

Background: Methotrexate (MTX) is one of the frequently used chemotherapeutic agents, especially in hematological malignancies and solid tumors. Objectives: MTX hepatotoxicity symptoms range from elevations in serum aminotransferases to hepatocyte necrosis and fibrosis. The time of medication administration significantly impacts treatment outcomes. Hence this study evaluated the protective eff...

Current study was aimed to evaluating protective effects of cornus mas fruit extract (CMFE) in mice treated with methotrexate (MTX). For this purpose, 48 young mature male mice were divided into 6 groups. Control group received only normal saline (0.1 mLper day, intraperitoneally), and the second group was administered MTX (20 mg kg-1 perweek, intraperitoneally). The third, ...

background:methotrexate (mtx) is one of the most commonly used disease-modifying antirheumatic drugs in the treatment of rheumatoid arthritis (ra) which can be associated with toxic effects on different organs. this study was designed to investigate the hepatotoxic effects in ra patients treated with mtx. methods: in this cross-sectional observational study, ra patients who received standard do...