نتایج جستجو برای: msu

تعداد نتایج: 928  

2013
Valérie Gagné Louis Marois Jean-Michel Levesque Hugo Galarneau Mireille H Lahoud Irina Caminschi Paul H Naccache Philippe Tessier Maria JG Fernandes

INTRODUCTION Monosodium urate crystals (MSU), the etiological agent of gout, are one of the most potent proinflammatory stimuli for neutrophils. The modulation of MSU-induced neutrophil activation by inhibitory receptors remains poorly characterized. The expression of the myeloid inhibitory C-type lectin-like receptor (MICL) in neutrophils is downregulated by several proinflammatory stimuli, su...

2017
Jeffrey W. Dwyer Dawn Contreras Cheryl L. Eschbach Holly Tiret Cathy Newkirk Erin Carter Linda Cronk

PROBLEM The Affordable Care Act charged the Agency for Healthcare Research and Quality to create the Primary Care Extension Program, but did not fund this effort. The idea to work through health extension agents to support health care delivery systems was based on the nationally known Cooperative Extension System (CES). Instead of creating new infrastructure in health care, the CES is an ideal ...

2015
Carlos Pineda Arturo J Fuentes-Gómez Cristina Hernández-Díaz Yessica Zamudio-Cuevas Javier Fernández-Torres Ambar López-Macay Ismael Alba-Sánchez Javier Camacho-Galindo Lucio Ventura Luis E Gómez-Quiróz María Concepción Gutiérrez-Ruíz Francisco García-Vázquez Anthony M Reginato Marwin Gutiérrez Alberto López-Reyes

INTRODUCTION Gout is an inflammatory condition induced by the deposition of monosodium urate (MSU) crystals in the joints and soft tissues that can produce acute or chronic arthritis. Several animal models of crystal-induced inflammation have been proposed that involve direct injection of MSU-crystals into different anatomical structures; however, only a few of these models reflect a true diart...

Journal: :Arthritis & rheumatology 2014
Laurent L Reber Thomas Marichal Jeremy Sokolove Philipp Starkl Nicolas Gaudenzio Yoichiro Iwakura Hajime Karasuyama Lawrence B Schwartz William H Robinson Mindy Tsai Stephen J Galli

OBJECTIVE Gouty arthritis is caused by the precipitation of monosodium urate monohydrate (MSU) crystals in the joints. While it has been reported that mast cells (MCs) infiltrate gouty tophi, little is known about the actual roles of MCs during acute attacks of gout. This study was undertaken to assess the role of MCs in a mouse model of MSU crystal-induced acute arthritis. METHODS We assesse...

2018
Penny Wang Stacy E Smith Rajesh Garg Fengxin Lu Alyssa Wohlfahrt Anarosa Campos Kathleen Vanni Zhi Yu Daniel H Solomon Seoyoung C Kim

Objectives Dual-energy CT (DECT) scan is a sensitive and specific tool used to visualise and quantify monosodium urate (MSU) crystal deposits in the joints. Few studies have examined MSU crystal deposits in patients with asymptomatic hyperuricemia (ie, hyperuricemia in the absence of gout) using DECT. Methods We conducted a prospective, non-interventional cross-sectional study to detect MSU c...

2015
Lauri J. Moilanen Mari Hämäläinen Lauri Lehtimäki Riina M. Nieminen Eeva Moilanen

INTRODUCTION In gout, monosodium urate (MSU) crystals deposit intra-articularly and cause painful arthritis. In the present study we tested the hypothesis that Transient Receptor Poten-tial Ankyrin 1 (TRPA1), an ion channel mediating nociceptive signals and neurogenic in-flammation, is involved in MSU crystal-induced responses in gout by utilizing three experi-mental murine models. METHODS Th...

2015
S. V. Vinogradova R. A. Soldatov

S.V. Vinogradova Moscow State University, Faculty of Bioengineering and Bioinformatics, 119991, Moscow, GSP-1, Leninskiye Gory, MSU, 1-73 [email protected] R.A. Soldatov Moscow State University, Faculty of Bioengineering and Bioinformatics, 119991, Moscow, GSP-1, Leninskiye Gory, MSU, 1-73 [email protected] M.A. Mironov Moscow State University, Faculty of Bioengineering and Bioinformatics, 119991...

2013
Dur-Zong Hsu Si-Jin Chen Pei-Yi Chu Ming-Yie Liu

Sesame oil has been used in traditional Taiwanese medicine to relieve the inflammatory pain in people with joint inflammation, toothache, scrapes, and cuts. However, scientific evidence related to the effectiveness or action mechanism of sesame oil on relief of pain and inflammation has not been examined experimentally. Here, we investigated the therapeutic effect of sesame oil on monosodium ur...

2015
Jia-Hau Yen Ling-Chung Lin Meng-Chi Chen Zsolt Sarang Pui-Ying Leong I-Chang Chang Jeng-Dong Hsu Jiunn-Horng Chen Yu-Fan Hsieh Anna Pallai Krisztina Köröskényi Zsuzsa Szondy Gregory J Tsay

INTRODUCTION Transglutaminase 2 (TG2), a protein crosslinking enzyme with multiple biochemical functions, has been connected to various inflammatory processes. In this study, the involvement of TG2 in monosodium urate (MSU) crystal-induced inflammation was studied. METHODS Immunohistochemistry, reverse transcription-polymerase chain reaction (RT-PCR) were performed to detect TG2 expression in...

2012
Christine Schorn Christina Janko Melanie Latzko Ricardo Chaurio Georg Schett Martin Herrmann

Neutrophil extracellular traps (NETs) are fibers of extracellular DNA released from neutrophils due to overwhelming phagocytic stimuli. The function of NETs is to trap and kill microbes to avoid spreading of potential pathogens. NETs are formed after encounter with various gram-positive and -negative bacteria but also in response to mediators causing sterile inflammation like interleukin-8 (IL-...

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