نتایج جستجو برای: msfc
تعداد نتایج: 131 فیلتر نتایج به سال:
The primary clinical outcome measure for evaluating multiple sclerosis in clinical trials has been Kurtzke's expanded disability status scale (EDSS). New therapies appear to favourably impact the course of multiple sclerosis and render continued use of placebo control groups more difficult. Consequently, future trials are likely to compare active treatment groups which will most probably requir...
The effect of delayed-release dimethyl fumarate (DMF; also known as gastro-resistant DMF) on the Multiple Sclerosis Functional Composite (MSFC) was assessed using integrated Phase 3 DEFINE and CONFIRM data. Patients treated with DMF (n = 769) demonstrated significant superiority on the MSFC, and each component, compared with placebo (n = 771) over two years: mean change for DMF vs placebo was 0...
BACKGROUND There are a number of instruments that describe severity and progression of multiple sclerosis and they are increasingly used as endpoints to assess the effectiveness of therapeutic interventions. We examined to what extent the psychometric properties of two accepted instruments--EDSS and MSFC--meet methodological standards and the value they have in clinical trials. METHODS We con...
OBJECTIVE To explore the relationship between the Multiple Sclerosis Functional Composite (MSFC), which is comprised of 3 clinical dimensions (arm and hand function, leg function and ambulation, cognition), and an everyday functional skill, driving performance. DESIGN Cohort study. SETTING Medical rehabilitation research organization. PARTICIPANTS Twenty-nine individuals with documented m...
To compare working methodologies between the cost engineering functions in NASA Marshall Space Flight Center (MSFC) and ESA European Space Research and Technology Centre (ESTEC), as well as to set-up cost cngi~iccri~~g ciipbiiiiies fur future manned Mars projects and other studies which involve similar subsystem technologies in MSFC and ESTEC, a demonstration cost estimate exercise was organize...
To monitor multiple sclerosis (MS) disability, scales like the Expanded Disability Status Scale (EDSS) and Multiple Sclerosis Functional Composite (MSFC) are commonly used. Both rely on a single clinical assess- ment in time which may not reflect patient’s performance their living environment. They also require training consuming. The SenseWear armband incorporates triaxial accelerometer sensit...
Document clustering is a fundamental operation used in unsupervised document organization, automatic topic extraction and information retrieval. But most clustering technologies are limited in their application on the static document collection. Intelligence analysts are currently overwhelmed with tremendous amount of text information streams generated everyday. There is a lack of comprehensive...
Authors Matthew McQuinn (Harvard/CFA, [email protected], phone: 617-495-2536), Joshua S. Bloom (UC Berkeley), Jonathan Grindlay (Harvard/CFA), David Band (GSFC), S.D. Barthelmy (GSFC), E. Berger (Harvard-CfA), A. Corsi (INAF-Roma), S. Covino (INAF-Brera), G.J. Fishman (MSFC), Steven R. Furlanetto (UCLA), Neil Gehrels (GSFC), D.H. Hartmann (Clemson), Chryssa Kouveliotou (MSFC), A.S. Kutyr...
OBJECTIVE To compare the driving performance using a driving simulator with physical and cognitive functions as measured by the Expanded Disability Status Scale (EDSS) and the Multiple Sclerosis Functional Composite (MSFC) in patients suffering from the relapsing-remitting form of multiple sclerosis (RRMS). METHODS 31 RRMS patients (18 women, 13 men, mean age 35.6 +/- 8.3 years, EDSS 2.8 +/- ...
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