نتایج جستجو برای: msa model
تعداد نتایج: 2106435 فیلتر نتایج به سال:
Multiple system atrophy (MSA) is a rapidly progressive neurodegenerative disorder characterized by widespread oligodendroglial cytoplasmic inclusions of filamentous α-synuclein, and neuronal loss in autonomic centres, basal ganglia and cerebellar circuits. It has been suggested that primary oligodendroglial α-synucleinopathy may represent a trigger in the pathogenesis of MSA, but the mechanisms...
Multiple system atrophy (MSA) is a fatal rapidly progressive α-synucleinopathy, characterized by α-synuclein accumulation in oligodendrocytes. It is accepted that the pathological α-synuclein accumulation in the brain of MSA patients plays a leading role in the disease process, but little is known about the events in the early stages of the disease. In this study we aimed to define potential ro...
1 Markov Random Field Model The following section will outline the mathematical model in our contact prediction method that is essentially identical to the plmDCA (Ekeberg et al., 2013) and GREMLIN (Kamisetty et al., 2013) methods. We eliminate transitive interactions in the observed interaction network by learning a generative model of the MSA using a Markov Random Field (MRF). Assuming we hav...
Multiple sequence alignments have primary role in several domains of modern molecular biology such as protein 3D structure/function prediction, phylogeny inference, molecular function, intermolecular interactions and many other common tasks in sequence analysis. Presently, many tools to construct multiple sequence alignments are available but none of them is accurate for all types of data sets....
Evolutionary trees are frequently used as the underlying model in the design of algorithms, optimization criteria and software packages for multiple sequence alignment (MSA). In this paper , we reexamine the suitability of trees as a universal model for MSA in light of the broad range of biological questions that MSA's are used to address. A tree model consists of a tree topology and a model of...
BACKGROUND Resistance to microtubule-stabilizing agents is a major hurdle for successful cancer therapy. We investigated combined treatment of microtubule-stabilizing agents (MSAs) with inhibitors of angiogenesis to overcome MSA resistance. METHODS Treatment regimens of clinically relevant MSAs (patupilone and paclitaxel) and antiangiogenic agents (everolimus and bevacizumab) were investigate...
We present a dialectal Egyptian Arabic to English statistical machine translation system that leverages dialectal to Modern Standard Arabic (MSA) adaptation. In contrast to previous work, we first narrow down the gap between Egyptian and MSA by applying an automatic characterlevel transformational model that changes Egyptian to EG′, which looks similar to MSA. The transformations include morpho...
Multiple system atrophy (MSA) is a progressive neurodegenerative disease presenting clinically with parkinsonian, cerebellar, and autonomic features. α-Synuclein (αsyn), encoded by the gene SNCA, is the main constituent of glial cytoplasmic inclusion (GCI) found in oligodendrocytes in MSA, but the methods of its accumulation have not been established. The aim of this study is to investigate alt...
We present an application of ABS algorithms for multiple sequence alignment (MSA). The Markov decision process (MDP) based model leads to a linear programming problem (LPP), whose solution is linked to a suggested alignment. The important features of our work include the facility of alignment of multiple sequences simultaneously and no limit for the length of the sequences. Our goal here is to ...
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