Multiplication-stimulating activity (MSA) is the name given to a family of polypeptides with a molecular weight of approximately 10,000 that have been isolated from the culture medium of a rat liver cell line. MSA stimulates growth and DNA synthesis in chick embryo fibroblasts and has weak insulin-like metabolic activity. We have purified MSA and characterized the binding of ‘““I-labeled MSA to...

Multiple system atrophy (MSA) is an adult-onset neurodegenerative disorder that has both clinical and pathological variants. Clinical examples include MSA with predominant cerebellar ataxia (MSA-C) and MSA with predominant parkinsonism (MSA-P), whereas olivopontocerebellar atrophy and striatonigral degeneration represent pathological variants. We performed systematic reviews of studies that add...

Multiple Sequence Alignment (MSA) is a fundamental tool of bioinformatics. Row-Column MSA (RC-MSA) methods such as CLUSTALW [12] produce tabular alignments that are now familiar. However, these methods have a number of shortcomings, including difficulty of understanding the result, high computational complexity, questionable assumptions, and other artifacts (such as poor handling of prefixand s...

Cognitive impairment and affective dysfunction of multiple system atrophy (MSA) and cortical cerebellar atrophy (CCA) have not been simultaneously examined comparing standard test batteries and a sensitive tool to detect subtle cognitive decline in patients. In the present study, we simultaneously examined cognitive and affective ability in MSA with predominant cerebellar ataxia (MSA-C, n=25), ...

The reasons for the differences in emphasis on striatonigral or olivopontocerebellar involvement in multiple system atrophy (MSA) remain to be determined. Semi-quantitative pathological analyses carried out in the United Kingdom and Japan demonstrated that olivopontocerebellar-predominant pathology was more frequent in Japanese MSA than British MSA. This observation provides evidence for a diff...

this paper presents an efficient mechanism to convert sana’ani dialect to modern standard arabic. the mechanism is based on morphological rules related to sana’ani dialect as well as modern standard arabic. such rules facilitate the dialect conversion to its corresponding msa. the mechanism tokenizes the input dialect text and divides each token into stem and its affixes; such affixes can be ca...

BACKGROUND Both homeless women and women who have experienced military sexual assault (MSA) are at high risk of serious psychological sequelae. However, little is known about the combined impact of MSA and current homelessness on psychological distress, or about distinctive treatment preferences among homeless female veterans affected by MSA. METHODS This observational study compared clinical...

UNLABELLED Cognitive dysfunction may occur in 17-40% of patients with multiple system atrophy (MSA). It has been suggested a milder cognitive impairment in cerebellar (MSA-C) than in parkinsonian variant (MSA-P). However, differences in cognitive profiles remain under discussion. OBJECTIVE To evaluate cognitive features in a series of patients with "probable MSA" from Argentina. METHOD Afte...

We examined the density of striatal presynaptic monoaminergic terminals, using a ligand for the type 2 vesicular monoamine transporter, (+)-[11C]dihydrotetrabenazine, with positron emission tomography in 7 normal control subjects, 8 multiple system atrophy (MSA) patients with predominantly parkinsonian features (MSA-P), 8 MSA patients with principally cerebellar dysfunction (MSA-C), and 6 spora...